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Strongyloides stercoralis hyperinfection syndrome: a case series and a review of the literature

Geri, Guillaume, Rabbat, Antoine, Mayaux, Julien, Zafrani, Lara, Chalumeau-Lemoine, Ludivine, Guidet, Bertrand, Azoulay, Elie, Pène, Frédéric·2015·Infection
DOI 10.1007/s15010-015-0799-1
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Abstract

Background Strongyloides stercoralis may lead to overwhelming infestation [Strongyloides hyperinfection syndrome (SHS)]. We aimed at describing a case series of patients admitted in intensive care unit (ICU) with SHS and report a literature review of such cases. Patients and methods Retrospective multicenter study of 11 patients admitted to the ICU of tertiary hospitals with SHS between 2000 and 2013. Literature review with Pubmed retrieved 122 cases. Logistic regression analysis was performed to identify predictive factors of ICU mortality and shock occurrence. Results 133 patients [median age 53 (39, 64), 72.2 % males] were included. Underlying immunosuppression was present in 127 patients, mostly long-term corticosteroid treatment in 111 (83.5 %) patients. Fever (80.8 %), respiratory (88.6 %), and gastrointestinal (71.2 %) symptoms were common clinical manifestations. Shock occurred in 75 (57.3 %) patients and mechanical ventilation was required in 89 (67.9 %) patients. Hypereosinophilia and a concomitant bacterial infection were observed in 34 (34.3 %) and 51 (38.4 %) patients, respectively. The in-ICU mortality rate was 60.3 %. Predictive factors of ICU mortality were shock occurrence [Odds ratio (OR) 18.1, 95 % confidence interval (95 % CI) 3.03-107.6, p Conclusion SHS remains associated with a poor outcome, especially when associated with shock and mechanical ventilation. Deterioration to shock is often related to concomitant bacterial infection. The poor outcome of es…

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Metadata

Authors
Geri, G., Rabbat, A., Mayaux, J., Zafrani, L., Chalumeau-Lemoine, L., Guidet, B., Azoulay, E., & Pène, F.
ORCID
Geri, Guillaume
Venue
Infection
Publisher
Springer Science and Business Media LLC
Published
2015-05-26
Volume
43
Issue
6
Pages
691-698
ISSN
  • 0300-8126
  • 1439-0973
DOI
10.1007/s15010-015-0799-1
Cited by
118
References
0
Language
en
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CoChat. (2026). Citation check: Strongyloides stercoralis hyperinfection syndrome: a case series and a review of the literature. https://app.cochat.ai/papers/10.1007/s15010-015-0799-1
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Geri, G., Rabbat, A., Mayaux, J., Zafrani, L., Chalumeau-Lemoine, L., Guidet, B., Azoulay, E., & Pène, F. (2015). Strongyloides stercoralis hyperinfection syndrome: a case series and a review of the literature. Infection. https://doi.org/10.1007/s15010-015-0799-1