Cited by 195Antibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyUrinary Tract Infections Management

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Cefiderocol: A Novel Agent for the Management of Multidrug-Resistant Gram-Negative Organisms

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Wu, Janet Y., Srinivas, Pavithra, Pogue, Jason M.·2020·Infectious Diseases and Therapy

DOI 10.1007/s40121-020-00286-6PMC PMC7054475

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Abstract

Cefiderocol, formerly S-649266, is a first in its class, an injectable siderophore cephalosporin that combines a catechol-type siderophore and cephalosporin core with side chains similar to cefepime and ceftazidime. This structure and its unique mechanism of action confer enhanced stability against hydrolysis by many β-lactamases, including extended spectrum β-lactamases such as CTX-M, and carbapenemases such as KPC, NDM, VIM, IMP, OXA-23, OXA-48-like, OXA-51-like and OXA-58. Cefiderocol's spectrum of activity encompasses both lactose-fermenting and non-fermenting Gram-negative pathogens, including carbapenem-resistant Enterobacterales. Cefiderocol recently received US Food and Drug Administration approval for the treatment of complicated urinary tract infections, including pyelonephritis, and is currently being evaluated in phase III trials for nosocomial pneumonia and infections caused by carbapenem-resistant Gram-negative pathogens. The purpose of this article is to review existing data on the mechanism of action, microbiology, pharmacokinetics, pharmacodynamics, efficacy, and safety of cefiderocol to assist clinicians in determining its place in therapy.

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“The understanding of EcoFiu and its orthologs will aid the further development of siderophore antibiotics (Lasko and Nicolau, 2020; Morris et al., 2020; Wu et al., 2020; Mabayoje et al., 2021) such as FDC.”
Background
Cefiderocol Dosing for Patients Receiving Continuous Renal Replacement Therapy
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Authors: Wu, J. Y., Srinivas, P., & Pogue, J. M.
Affiliations: Cleveland Clinic (US)
University of Michigan (US)
Corresponding author: Wu, Janet Y.
ORCID: Wu, Janet Y.
Srinivas, Pavithra
Pogue, Jason M.
Venue: Infectious Diseases and Therapy
Publisher: Springer Science and Business Media LLC
Published: 2020-02-18
Volume: 9
Issue: 1
Pages: 17-40
ISSN: 2193-6382 (ISSN-L)
2193-8229
DOI: 10.1007/s40121-020-00286-6
PMC: PMC7054475
OpenAlex: W3008901682
Cited by: 195
References: 45
Citations by year: 2026: 25 · 2025: 25 · 2024: 25 · 2023: 37 · 2022: 36 · 2021: 28 · 2020: 18
FWCI: 2.10
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/4.0 (tdm)
creativecommons.org/licenses/by-nc/4.0 (vor)
Locations: Infectious Diseases and Therapy (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Health Sciences › Medicine › Pharmacology (medical) › Antibiotics Pharmacokinetics and Efficacy
Health Sciences › Medicine › Urology › Urinary Tract Infections Management
Keywords: cefiderocol, siderophore cephalosporin, multidrug-resistant Gram-negative bacteria, carbapenem resistance, extended-spectrum beta-lactamase, carbapenemase, mechanism of action, pharmacokinetics, pharmacodynamics, complicated urinary tract infection, nosocomial pneumonia, Enterobacterales, drug safety and efficacy

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Cefiderocol: A Novel Agent for the Management of Multidrug-Resistant Gram-Negative Organisms

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