The Role and Diagnosis of Allergic Contact Dermatitis in Patients with Atopic Dermatitis
Open accessAbstract
Patients with atopic dermatitis (AD) have increased penetration of allergens, immune dysregulation (including shared cytokine pathways), and frequent use of emollients and topical medications, all of which may predispose toward developing allergic contact dermatitis (ACD). Recent systematic reviews have suggested that ACD is a significant clinical problem in both children and adults with AD. While this remains controversial, ACD remains an important comorbidity and potential exacerbant of AD in clinical practice. Common relevant allergens, include lanolin, neomycin, formaldehyde, sesquiterpene lactone mix, compositae mix, and fragrances that are commonly found in AD patients' personal care products. We herein review the clinical scenarios where patch testing is indicated in AD. In addition, we review the contraindications, preferred patch-testing series, pitfalls, and challenges determining the relevance of positive patch-test reactions in AD patients.
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Historically, ACD was thought to be primarily driven by the TH1 inflammatory response; however, it is now known that TH2, TH9, TH17, and TH22 also may play a role in its pathogenesis.
“Historically, ACD was thought to be primarily driven by the T H 1 inflammatory response; however, it is now known that T H 2, T H 9, T H 17, and T H 22 also may play a role in its pathogenesis.4,5”
From Dupilumab for Allergic Contact Dermatitis: An Overview of Its Use and Impact on Patch Testing. (2022) · cites this paper as [5]
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References 113 · Cited by 163
- Authors
- Owen, J. L., Vakharia, P. P., & Silverberg, J. I.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Silverberg, Jonathan I.
- Venue
- American Journal of Clinical Dermatology
- Published
- 2018-01-05
- Volume
- 19
- Issue
- 3
- Pages
- 293-302
- ISSN
- 1175-0561 (ISSN-L)
- 1179-1888
- PMC
- PMC5948135
- OpenAlex
- W2781752850
- Cited by
- 163
- References
- 113
- Citations by year
- 2026: 5 · 2025: 27 · 2024: 22 · 2023: 19 · 2022: 23 · 2021: 28 · 2020: 18 · 2019: 13 · 2018: 5 · 2017: 1
- FWCI
- 17.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Clinical Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Agency for Healthcare Research and Quality (K12 HS023011)
- Dermatology Foundation
- Topics
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
- Keywords
- allergic contact dermatitis, atopic dermatitis, patch testing, allergen penetration, neomycin, lanolin, formaldehyde, sesquiterpene lactones, fragrance allergens, personal care products, patch test interpretation
- MeSH terms
- Adult, Allergens, Child, Dermatitis, Atopic, Emollients, Humans, Patch Tests, Skin, Comorbidity, Incidence, Dermatitis, Allergic Contact, Disease Progression
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