The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The Effect of Discrimination on Likelihood of Participation in a Clinical Trial
Open accessAbstract
Objectives Despite efforts to increase minority enrollment in research, racial disparities still exist, and a belief persists that minorities are inherently less likely to enroll in medical research. This lingering view may impact the manner in which studies are presented to minority patients. This study aimed to assess racial differences in reported discrimination while seeking medical care and likelihood to participate in a medical research study.Methods 844 residents were enrolled via convenience sampling, and asked to complete a survey designed to examine perceived discrimination while seeking healthcare and likelihood to participate (LoP) in a medical research study.Results Participants who reported worse treatment than other races had lower mean LoP scores (53.7 ± 17.6) than participants who reported being treated the same as (61.1 ± 16.1) or better than (64.0 ± 15.0) other races (p < .001). There were no significant differences in mean LoP score by race/ethnicity. The interaction of race with discrimination had no significant effect on mean LoP (p = 0.8). There was a statistically significant association between race and discrimination (X 2 = 11.32, p = 0.023), although the majority of participants reported no discrimination.Conclusion Patient experiences in the medical arena may have an impact on their willingness to join a medical study. An effective strategy to increase minority participation in research may be to work with investigators and staff on implicit bias with regard to minority patients. Further research should focus on the impact of research staff interactions on an individual's decision-making process.
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George, S., Duran, N., & Norris, K. (2014) · American Journal of Public Health · doi:10.2105/ajph.2013.301706 · Cited by 1,603
More than Tuskegee: Understanding Mistrust about Research Participation
Scharff, D. P., Mathews, K. J., Jackson, P., Hoffsuemmer, J., Martin, E., & Edwards, D. F. (2010) · Journal of Health Care for the Poor and Underserved · doi:10.1353/hpu.0.0323 · Cited by 1,290
2005 American Community Survey 1-Year Estimates
(2016) · Cited by 1,241
Prior Experiences of Racial Discrimination and Racial Differences in Health Care System Distrust
Armstrong, K., Putt, M., Halbert, C. H., Grande, D., Schwartz, J. S., Liao, K., Marcus, N., Bristol, M. N., & Shea, J. A. (2012) · Medical Care · doi:10.1097/mlr.0b013e31827310a1 · Cited by 328
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Perceived Discrimination and Adherence to Medical Care in a Racially Integrated Community
Casagrande, S. S., Gary‐Webb, T. L., LaVeist, T. A., Gaskin, D. J., & Cooper, L. A. (2007) · Journal of General Internal Medicine · doi:10.1007/s11606-006-0057-4 · Cited by 244
Perceived Discrimination in Health Care and Health Status in a Racially Diverse Sample
Hausmann, L. R. M., Jeong, K., Bost, J. E., & Ibrahim, S. A. (2008) · Medical Care · doi:10.1097/mlr.0b013e3181792562 · Cited by 237
The Tuskegee Legacy Project: Willingness of Minorities to Participate in Biomedical Research
Katz, R. V., Kegeles, S. S., Kressin, N. R., Green, B. L., Wang, M. Q., James, S. A., Russell, S. L., & Claudio, C. (2006) · Journal of Health Care for the Poor and Underserved · doi:10.1353/hpu.2006.0126 · Cited by 218
Purnell, J. Q., Peppone, L. J., Alcaraz, K. I., McQueen, A., Guido, J. J., Carroll, J. K., Shacham, E., & Morrow, G. R. (2012) · American Journal of Public Health · doi:10.2105/ajph.2012.300694 · Cited by 132
Eshera, N., Itana, H., Zhang, L., Soon, G., & Fadiran, E. O. (2015) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000000177 · Cited by 82
Research works printed but not linked: 1
- Parker K, Horowitz JM, Morin R, Lopez MH. Multiracial in America: The Many Dimensions of Hispanic Racial Identity. Pew Research Center. 2015. [Available from: https://www.pewsocialtrends.org/2015/06/11/chapter-7-the-many-dimensions-of-hispanic-racial-identity/.
Cited by
Alarcón Garavito, G. A., Gilchrist, K., Ciurtin, C., Khanna, S., Chambers, P., McNally, N., Merivale, E., Carr, E., Yu, R., & Vindrola-Padros, C. (2025) · Trials · doi:10.1186/s13063-025-08769-y · Cited by 42
“Twenty-four papers reported information on why patients might decline invitations to participate in clinical trials [9–11, 16, 17, 32–34, 39, 42–47, 51, 52, 57– 59, 61, 63, 65, 69].”
Metadata
- Authors
- Devlin, A., Gonzalez, E., Ramsey, F., Esnaola, N., & Fisher, S.
- Affiliations
- Temple University (US)
- Fox Chase Cancer Center (US)
- Corresponding author
- Devlin, Amie
- Venue
- Journal of Racial and Ethnic Health Disparities
- Published
- 2020-03-10
- Volume
- 7
- Issue
- 6
- Pages
- 1124-1129
- ISSN
- 2196-8837 (ISSN-L)
- 2197-3792
- PMC
- PMC7805541
- OpenAlex
- W3012379875
- Cited by
- 15
- References
- 11
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 1
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Racial and Ethnic Health Disparities (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (P30 CA006927)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ethics in Clinical Research
- Social Sciences › Sociology and Political Science › Racial and Ethnic Identity Research
- Social Sciences › Anthropology › Race, Genetics, and Society
- Keywords
- racial discrimination, minority participation in clinical trials, willingness to participate in research, implicit bias, medical residents, race and ethnicity
- MeSH terms
- Adult, Aged, Clinical Trials as Topic, Female, Hispanic or Latino, Humans, Male, Middle Aged, Minority Groups, Surveys and Questionnaires, Patient Selection, Racism
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- Devlin, A., Gonzalez, E., Ramsey, F., Esnaola, N., & Fisher, S. (2020). The Effect of Discrimination on Likelihood of Participation in a Clinical Trial. Journal of Racial and Ethnic Health Disparities. https://doi.org/10.1007/s40615-020-00735-5
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