The DOI matches its Crossref record; 43 of the 44 references it cites were found in a registry or an index.
A 2019 update on TSH-secreting pituitary adenomas
Abstract
Thyrotropin-secreting pituitary adenomas (TSH-omas) present with signs and symptoms of hyperthyroidism and they are characterized by elevated serum levels of free thyroid hormones with measurable TSH levels. TSH-omas are very infrequent, accounting for less than 1% of all pituitary adenomas, thus representing a very rare cause of hyperthyroidism. For this reason, data collected on these rare disorders are relatively few, but some new researches shed new light on the etiopathogenesis, the diagnosis and the treatment of such a remarkable disease. Since the same biochemical picture is present in the syndromes of thyroid hormone resistance (RTH), in particular in the form of pituitary RTH, failure in distinguishing these clinical entities may lead to improper patient management. Conversely, early diagnosis and correct treatment of TSH-omas may prevent the occurrence of neurological and endocrinological complications, thus leading to a better rate of cure. In the present short review article, the most relevant recent advances in the pathophysiology of TSH-omas are described.
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“Treatment for TSH-omas involves neurosurgical intervention, and corticosteroid therapy is used to treat Addison's disease.69,71,85”
From Refractory hypothyroidism: unraveling the complexities of diagnosis and management (2023) · cites this paper as [71]
In the citing paper
“Treatment for TSH-omas involves neurosurgical intervention, and corticosteroid therapy is used to treat Addison's disease.69,71,85”
From Refractory hypothyroidism: unraveling the complexities of diagnosis and management (2023) · cites this paper as [71]
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Pitfalls in the measurement and interpretation of thyroid function tests
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Beck‐Peccoz, P., Lania, A. G., Beckers, A. M., Chatterjee, K., & Wémeau, J.-L. (2013) · European Thyroid Journal · doi:10.1159/000351007 · Cited by 279
Self-citationThe changing spectrum of TSH-secreting pituitary adenomas: diagnosis and management in 43 patients
Socin, H., Chanson, P., Delemer, B., Tabarin, A., Rohmer, V, Mockel, J., Stevenaert, A., & Beckers, A. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1480433 · Cited by 274
Interferences With Thyroid Function Immunoassays: Clinical Implications and Detection Algorithm
Favresse, J., Burlacu, M.-C., Maiter, D., & Gruson, D. (2018) · Endocrine Reviews · doi:10.1210/er.2018-00119 · Cited by 258
National Incidence and Prevalence of TSH-Secreting Pituitary Adenomas in Sweden
Önnestam, L., Berinder, K., Burman, P., Dahlqvist, P., Engström, B. E., Wahlberg, J., & Nyström, H. F. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3362 · Cited by 148
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Research works printed but not linked: 2
- Beck-Peccoz P, Lania A, Persani L (2015) Chapter 24. TSH-producing adenomas. In: Jameson JL, DeGroot LJ (eds) Endocrinology, 7th edn. W.B. Saunders Pub, Philadelphia, pp 266–274
- Gurnell M, Visser TJ, Beck-Peccoz P, Chatterjee VKK (2015) Resistance to thyroid hormone: in endocrinology, adult and pediatric. In: Jameson LJ, DeGroot LJ (eds), 7th edn, vol II. Elsevier, Philadelphia pp 1648–1665
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Peng, G., Guo, C., Lv, Y., Li, D., Zhou, L., Shen, R., Chen, Y., Zheng, X., Sun, Z., Zheng, H., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22603712
Maione, L. (2025) · EMC - Endocrinologie - Nutrition · doi:10.1016/s1155-1941(24)44348-5
Li, Y., Zhang, K., Chai, X., Liu, H., Cheng, X., Wang, X., Chi, Y., Li, N., & Lian, X. (2026) · Endocrine · doi:10.1007/s12020-026-04579-7
Đukić, M., Kovačević, Z., Zibar, K., & Muzurović, E. M. (2026) · Cardiovascular Diabetology – Endocrinology Reports · doi:10.1186/s40842-026-00291-7
Ozkahraman, A. U., Pekmezci, A., Karatay, H., Akpinar, E., Erkan, B., Karagülle, M., Koçak, B., Niyazoğlu, M., & Hatipoğlu, E. (2026) · Pituitary · doi:10.1007/s11102-026-01691-9
Brain and Endocrine Crosstalk: Clinical Implication for Neurocritical Care
Tulskii, I., Kulikov, A., & Savin, I. (2026) · Physiology in clinical neurosciences · doi:10.1007/978-981-92-0763-3_13
Carvalho, J. F. D., Slack, D. J., Shrivastava, R. K., Richardson, T. E., Yokoda, R. T., & Levine, A. C. (2026) · JCEM Case Reports · doi:10.1210/jcemcr/luag129
Thyrotropin/growth hormone co-secreting pituitary adenoma with pancytopenia: a case report
Liu, J., Zhu, Y., Wei, Y., Yu, L., Li, Y., Wang, Q., Zhuang, L., Jin, G., & Pei, X. (2026) · Journal of Medical Case Reports · doi:10.1186/s13256-026-06160-2
G-García, M. E., Flores‐Martínez, Á., Arroyo-Millan, L., Venegas, E., Díaz-Perdigones, C. M., Maraver-Selfa, S., Cano, D., Arráez, C., Arráez, M. Á. E., Japón, M. Á., et al. (2026) · iScience · doi:10.1016/j.isci.2026.117055
Kawabata, I., Ogawa, J., Ichikawa, T., Kuwabara, Y., Motoda, N., Tahara, S., & Suzuki, S. (2026) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2026.03.026
Case Report: Development of a thyrotropinoma in a patient with thyroid hemiagenesis
Rozenek, E. B., Gurnell, M., Kunicki, J., Maksymowicz, M., Korbonits, M., Zgliczyński, W., & Stelmachowska‐Banaś, M. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1902011
Metadata
- Authors
- Beck-Peccoz, P., Giavoli, C., & Lania, A.
- Affiliations
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Humanitas University (IT)
- Corresponding author
- Lania, A.
- ORCID
- Venue
- Journal of Endocrinological Investigation
- Published
- 2019-06-07
- Volume
- 42
- Issue
- 12
- Pages
- 1401-1406
- ISSN
- 0391-4097 (ISSN-L)
- 1720-8386
- OpenAlex
- W2954800995
- Cited by
- 111
- References
- 44
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 16 · 2023: 27 · 2022: 14 · 2021: 17 · 2020: 12 · 2019: 3
- FWCI
- 1.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Endocrinological Investigation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Oncology › Neuroendocrine Tumor Research Advances
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Keywords
- TSH-secreting pituitary adenoma, TSHoma, hyperthyroidism, thyroid hormone resistance, etiopathogenesis, diagnosis, treatment, neurological complications
- MeSH terms
- Adenoma, Humans, Hyperthyroidism, Pituitary Neoplasms, Thyroid Hormones, Thyrotropin
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