Nanoliposomal Bcl-xL proteolysis-targeting chimera enhances anti-cancer effects on cervical and breast cancer without on-target toxicities
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Efferocytosis plays a crucial role in maintaining tissue homeostasis and in modulating immune responses.
“Efferocytosis, the process by which macrophages engulf and remove apoptotic cells (ACs), plays a crucial role in maintaining tissue homeostasis and in modulating immune responses.”
From Macrophage efferocytosis mediated by the TP63-RAC2 pathway promotes immunosuppressive remodeling in esophageal cancer (2026) · cites this paper as [5]
Cites
Programmed Anuclear Cell Death Delimits Platelet Life Span
Mason, K. D., Carpinelli, M. R., Fletcher, J. I., Collinge, J. E., Hilton, A. A., Ellis, S., Kelly, P. N., Ekert, P. G., Metcalf, D., Roberts, A. W., et al. (2007) · Cell · doi:10.1016/j.cell.2007.01.037 · Cited by 1,031 · see citing works
A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity
Khan, S., Zhang, X., Lv, D., Zhang, Q., He, Y., Zhang, P., Liu, X., Thummuri, D., Yuan, Y., Wiegand, J. S., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0668-z · Cited by 688 · see citing works
Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?
Churcher, I. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01272 · Cited by 491 · see citing works
Schoenwaelder, S. M., Jarman, K. E., Gardiner, E. E., Hua, M., Qiao, J., White, M. J., Josefsson, E. C., Alwis, I., Ono, A., Willcox, A., et al. (2011) · Blood · doi:10.1182/blood-2011-04-347849 · Cited by 351 · see citing works
Lipid-based nanoparticle formulations for small molecules and RNA drugs
Ickenstein, L. M., & Garidel, P. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1669558 · Cited by 193 · see citing works
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Xi, Y., Zhao, Z., Zhou, Y., Yin, C., Li, Y., Xu, X., Jin, W., Lin, C., Zhao, K., Kuang, J., et al. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102529 · Cited by 12 · see citing works
- Authors
- Zhang, J., Zhang, B., Pu, C., Cui, J., Huang, K., Wang, H., & Zhao, Y.
- Affiliations
- Wuhan Union Hospital (CN)
- Chengdu University of Traditional Chinese Medicine (CN)
- Corresponding author
- Wang, Hongbo
- Zhao, Yingchao
- Venue
- Advanced Composites and Hybrid Materials
- Published
- 2023-04
- Volume
- 6
- Issue
- 2
- ISSN
- 2522-0128 (ISSN-L)
- 2522-0136
- OpenAlex
- W4362582864
- Cited by
- 22
- References
- 5
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 15
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Advanced Composites and Hybrid Materials (publishedVersion)
- Funders
- National Natural Science Foundation of China (81974409, 81974463)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Degradation and Inhibitors
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- Bcl-xL, PROTACs, nanoliposomes, drug delivery, cervical cancer, triple-negative breast cancer, apoptosis, tumor growth inhibition, tissue distribution, on-target toxicity, drug solubility and bioavailability
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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