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International application of a new probability algorithm for the diagnosis of coronary artery disease

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Detrano, Robert, Janosi, Andras, Steinbrunn, Walter, Pfisterer, Matthias, Schmid, Johann-Jakob, Sandhu, Sarbjit, Guppy, Kern H., Lee, Stella, Froelicher, Victor·1989·The American Journal of Cardiology

Abstract

A new discriminant function model for estimating probabilities of angiographic coronary disease was tested for reliability and clinical utility in 3 patient test groups. This model, derived from the clinical and noninvasive test results of 303 patients undergoing angiography at the Cleveland Clinic in Cleveland, Ohio, was applied to a group of 425 patients undergoing angiography at the Hungarian Institute of Cardiology in Budapest, Hungary (disease prevalence 38%); 200 patients undergoing angiography at the Veterans Administration Medical Center in Long Beach, California (disease prevalence 75%); and 143 such patients from the University Hospitals in Zurich and Basel, Switzerland (disease prevalence 84%). The probabilities that resulted from the application of the Cleveland algorithm were compared with those derived by applying a Bayesian algorithm derived from published medical studies called CADENZA to the same 3 patient test groups. Both algorithms overpredicted the probability of disease at the Hungarian and American centers. Overprediction was more pronounced with the use of CADENZA (average overestimation 16 vs 10% and 11 vs 5%, p less than 0.001). In the Swiss group, the discriminant function underestimated (by 7%) and CADENZA slightly overestimated (by 2%) disease probability. Clinical utility, assessed as the percentage of patients correctly classified, was modestly superior for the new discriminant function as compared with CADENZA in the Hungarian group and similar in the American and Swiss groups. It was concluded that coronary disease probabilities derived from discriminant functions are reliable and clinically useful when applied to patients with chest pain syndromes and intermediate disease prevalence.

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Crossref · 10.1016/0002-9149(89)90524-9

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Metadata

Authors
Detrano, R., Janosi, A., Steinbrunn, W., Pfisterer, M., Schmid, J.-J., Sandhu, S., Guppy, K. H., Lee, S., & Froelicher, V.
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
1989-08
Volume
64
Issue
5
Pages
304-310
ISSN
0002-9149 (ISSN-L)
OpenAlex
W1989164753
Cited by
695
References
17
FWCI
5.91
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: International application of a new probability algorithm for the diagnosis of coronary artery disease. https://app.cochat.ai/papers/10.1016/0002-9149(89)90524-9
The paper
Detrano, R., Janosi, A., Steinbrunn, W., Pfisterer, M., Schmid, J.-J., Sandhu, S., Guppy, K. H., Lee, S., & Froelicher, V. (1989). International application of a new probability algorithm for the diagnosis of coronary artery disease. The American Journal of Cardiology. https://doi.org/10.1016/0002-9149(89)90524-9

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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