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Cited by 142Cardiovascular Function and Risk FactorsCardiovascular Effects of ExerciseBlood Pressure and Hypertension Studies

The DOI matches its Crossref record; 24 of the 25 references it cites were found in a registry or an index.

A new method for indexing left ventricular mass for differences in body size

Lauer, Michael S., Anderson, Keaven M., Larson, Martin G., Levy, Daniel·1994·The American Journal of Cardiology
DOI 10.1016/0002-9149(94)90909-1
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Abstract

Left ventricular (LV) mass is determined to a large extent by body size. This has created controversy regarding the optimal method of defining normal values in the clinical setting. Previous groups have advocated indexing LV mass for body surface area, lean body mass, or height, which is an obesity-independent measure of body size. This study describes a new approach that involves dividing LV mass by height raised to a noninteger power. In a sample of 387 men and 714 women who were between 20 and 45 years of age and who were free of cardiovascular disease, the height exponent was determined by logarithmic regression models to be 2.12 in men and 1.91 in women; in a pooled analysis, the height exponent was 1.97. This approach reduced male versus female differences in the mean and 95th percentile values for LV mass; mean value differences who reduced from 52% among raw values to 29% among adjusted values. Compared with height or body surface area indexation, it was found to slightly increase the correlation between LV mass and systolic blood pressure. In contrast, body surface area indexation reduced the association between LV mass and obesity. The current method of indexation is independent of obesity, reduces LV mass variability associated with body size and gender, and may therefore be a useful method for defining normal and abnormal values of LV mass in the clinical setting. The findings of this study also suggest that indexation of LV mass for body surface area is inappropriate.

Overview

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Crossref · 10.1016/0002-9149(94)90909-1

Cites

24 of 24 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 1

  1. SAS Institute Inc., 1989, Vol. 2, 1351

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Metadata

Authors
Lauer, M. S., Anderson, K. M., Larson, M. G., & Levy, D.
Affiliations
Cleveland Clinic (US)
Corresponding author
Levy, Daniel
ORCID
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
1994-09
Volume
74
Issue
5
Pages
487-491
ISSN
0002-9149 (ISSN-L)
DOI
10.1016/0002-9149(94)90909-1
OpenAlex
W1970355774
Cited by
142
References
25
Citations by year
2025: 1 · 2024: 2 · 2023: 6 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 1 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 5
FWCI
6.32
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
left ventricular mass, body size normalization, lean body mass, obesity, sex differences, systolic blood pressure, reference values, cardiovascular risk
MeSH terms
Adult, Body Height, Body Surface Area, Female, Heart Ventricles, Humans, Male, Reference Values, Regression Analysis, Ultrasonography, Body Mass Index

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