Nitrate effects on cardiac output and left ventricular outflow resistance in chronic congestive heart failure
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Organic nitrates release nitric oxide in the systemic circulation, reducing left ventricular filling pressure and increasing cardiac index through decreasing preload and afterload.
“the organic nitrates (e.g. glycerol trinitrate-GTN) releasing nitric oxide in the systemic circulation, reducing left ventricular filling pressure and increasing cardiac index suggesting improvement in cardiac performance (Franciosa et al. 1978) through decreasing both preload and afterload (Kelly et al. 1990).”
From Oral nitrate and citrulline decrease blood pressure and increase vascular conductance in young adults: a potential therapy for heart failure (2016) · cites this paper as Franciosa et al. 1978
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References 30 · Cited by 104
- Authors
- Franciosa, J. A., Blank, R. C., & Cohn, J. N.
- Corresponding author
- Franciosa, Joseph A.
- ORCID
- Cohn, Jay N.
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 1978-02
- Volume
- 64
- Issue
- 2
- Pages
- 207-213
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W1994223922
- Cited by
- 104
- References
- 30
- Citations by year
- 2018: 1 · 2017: 1 · 2016: 1 · 2013: 1
- FWCI
- 11.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart rate and cardiovascular health
- Keywords
- nitrate, congestive heart failure, cardiac output, left ventricular filling pressure, preload reduction, sodium nitroprusside, tourniquet, systemic vascular resistance, cardiac index, dilated cardiomyopathy, vasodilator therapy
- MeSH terms
- Adolescent, Aged, Cardiac Output, Chronic Disease, Heart Failure, Heart Ventricles, Hemodynamics, Humans, Male, Middle Aged, Nitrates, Nitroprusside, Tourniquets, Vascular Resistance
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