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Cited by 193Electrolyte and hormonal disordersHeart Failure Treatment and ManagementIon Transport and Channel Regulation

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Antidiuretic hormone in congestive heart failure.

Riegger, Günther A.J., Liebau, Gerhart, Kochsiek, Kurt·1982·The American Journal of Medicine
DOI 10.1016/0002-9343(82)90576-9
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Abstract

In advanced heart failure, severe edema develops associated with hyponatremia. In 20 patients with severe congestive heart failure, we studied plasma antidiuretic hormone (ADH) concentrations related to hemodynamics and plasma osmolality. Prazosin was used to test the acute response to changes in atrial receptors and hemofiltration to test the response to changes in volume receptors. One group of the patients had inappropriately high ADH values (14.5 +/- 8.8 pg/ml) in relation to their plasma osmolality, which was well below normal values (276 +/- 23 mosmol/kg water) with no apparent osmoregulatory control. The other group showed a normal relationship of ADH and plasma osmolality (3.9 +/- 1.0 pg/ml; 289 +/- 8 mosmol/kg water), Only in the normal regulating group did lowering of left atrium pressure by prazosin result in a rise in ADH related to the decrease in pressure. Inappropriately high ADH secretion could be reversed by hemofiltration. This suggests that the syndrome of "dilutional hypo-osmolality" in severe congestive heart failure may be caused by an inappropriately high ADH secretion in which the osmoreceptor system is dominated by nonosmolar stimuli; however, it cannot be ruled out that associated hemodynamic effects in the kidney or other intrarenal or hormonal factors contribute to this mechanism.

Overview

Integrity signals

Registry

Crossref · 10.1016/0002-9343(82)90576-9

Cites

25 of 25 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 3

  1. Bokyin, 1974, Mechanism of the diuretic effect of atrial tachycardia, Clin Res, 22, 265
  2. Yaron, 1978, Renal sodium handling in, acute right-sided heart failure in dogs, Min Electrolyt Metab, 1, 303
  3. Davis, 1965, The physiology of congestive heart failure, vol. 3

Cited by

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Metadata

Authors
Riegger, G. A. J., Liebau, G., & Kochsiek, K.
Corresponding author
Riegger, Günther A.J.
Venue
The American Journal of Medicine
Publisher
Elsevier BV
Published
1982-01
Volume
72
Issue
1
Pages
49-52
ISSN
0002-9343 (ISSN-L)
DOI
10.1016/0002-9343(82)90576-9
OpenAlex
W2011628654
Cited by
193
References
25
Citations by year
2025: 2 · 2023: 1 · 2021: 7 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 5 · 2012: 1
FWCI
17.96
Type
journal article
Language
en
Open access
closed
Licence
  • www.elsevier.com/tdm/userlicense/1.0/ (tdm)
  • www.elsevier.com/legal/tdmrep-license (tdm)
Locations
  • The American Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
Keywords
vasopressin, congestive heart failure, hyponatremia, plasma osmolality, prazosin, atrial receptors, hemofiltration, osmoregulation, left atrial pressure, volume receptors
MeSH terms
Adult, Edema, Heart Failure, Hemodynamics, Humans, Hyponatremia, Middle Aged, Osmolar Concentration, Prazosin, Vasopressins

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Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.