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Relation between variations in the phenotypic expression of an unstable hemoglobin disorder (hemoglobin Zürich) and carboxyhemoglobin levels
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“In haemoglobinopathies such as Hb Zurich, which is associated with haemolysis, CO may have a beneficial effect on haemolysis: as a result of the 65-fold increase in the affinity of the abnormal beta-globin chain of Hb Zurich for CO, the molecule is stabilized and exhibits resistance to oxidative injury, a decreased rate of haemolysis and a marked increase in oxygen affinity (Virshup et al., 1983;Z”
From Anaemia and cigarette smoking (2008) · cites this paper as Zinkham, Houtchens & Caughey, 1983
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Research works printed but not linked: 13
- Rieder, 1965, Hemoglobin Zürich: clinical, chemical and kinetic studies, Am J Med, 39, 4, 10.1016/0002-9343(65)90241-X · DOI
- Dickerman, 1973, Hemoglobin Zürich, Am J Med, 55, 638, 10.1016/0002-9343(73)90186-1 · DOI
- Zinkham, 1979, Observations on the rate and mechanism of hemolysis in individuals with Hb Zürich (His E7 (63) β→ Arg). I. Concentrations of haptoglobin and hemopexin in the serum, Johns Hopkins Med J, 144, 37
- Zinkham, 1979, Observations on the rate and mechanism of hemolysis in individuals with Hb Zürich (His E7 (63) β→ Arg). II. Thermal denaturation of hemoglobin as a cause of anemia during fever, Johns Hopkins Med J, 144, 109
- Jacob, 1970, The role of hemoglobin heme loss in Heinz body formation: studies with a partially hemedeficient hemoglobin and with genetically unstable hemoglobins, J Clin Invest, 49, 2008, 10.1172/JCI106421 · DOI
- Zinkham, 1980, Carboxyhemoglobin levels in an unstable hemoglobin disorder (Hb Zürich): effect on phenotypic expression, Science, 209, 406, 10.1126/science.7384813 · DOI
- Mancini, 1965, Immunochemical quantitation of antigens by single radial immunodiffusion, Immunochemistry, 2, 235, 10.1016/0019-2791(65)90004-2 · DOI
- Simpson, 1970, Rhodanile blue: a rapid and selective stain for Heinz bodies, Stain Technol, 45, 221, 10.3109/10520297009067482 · DOI
- Carrell, 1972, A simple method for the detection of unstable hemoglobins, Br J Haematol, 23, 615, 10.1111/j.1365-2141.1972.tb07096.x · DOI
- Wallace, 1976, Properties of hemoglobin A and hemoglobin Zürich (β63 Histidine→ Arginine): quantitative evaluation of functional abnormalities in hemoglobins, Biochem Biophys Res Commun, 68, 1379, 10.1016/0006-291X(76)90348-X · DOI
- White, 1971, The unstable hemoglobins—molecular and clinical features, Progr Hematol, 7, 69
- Coburn, 1964, Endogenous carbon monoxide production in patients with hemolytic anemia, J Clin Invest, 45, 460, 10.1172/JCI105360 · DOI
- Smith, 1978, Smoker's polycythemia, N Engl J Med, 298, 6, 10.1056/NEJM197801052980102 · DOI · Paper page
Cited by
LEIFERT, J. A. (2008) · International Journal of Laboratory Hematology · doi:10.1111/j.1751-553x.2008.01067.x · Cited by 83
Metadata
- Authors
- Zinkham, W. H., Houtchens, R. A., & Caughey, W. S.
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 1983-01
- Volume
- 74
- Issue
- 1
- Pages
- 23-29
- ISSN
- 0002-9343
- Cited by
- 9
- References
- 0
- Language
- en
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
