Lithium-associated thyrotoxicosis
Abstract
Primary hypothyroidism developed in a 57-year-old woman treated for eight years with lithium carbonate for manic-depressive illness, and nine months later she became thyrotoxic. Although autoimmune disease appeared to be responsible, lithium was suspected to play a contributory role in both phases of her illness. This is the first reported case of hyperthyroidism following hypothyroidism in a lithium-treated patient. The 24 reported cases of lithium-associated thyrotoxicosis and the possible mechanisms that may explain this poorly understood phenomenon are also reviewed.
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A case series of 24 patients with lithium-associated thyrotoxicosis identified GD in 12 (50%), painless thyroiditis in two patients, TMNG in three patients, and no identified etiology in seven patients.
“A case series of 24 patients with lithium-associated thyrotoxicosis identified GD in 12 (50%), painless thyroiditis in two patients, TMNG in three patients, and no identified etiology in seven patients (655).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [655]
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References 36 · Cited by 48
- Authors
- McDermott, M. T., Burman, K. D., Hofeldt, F. D., & Kidd, G. S.
- Affiliations
- Fitzsimons Army Medical Center (US)
- Walter Reed National Military Medical Center (US)
- University of Colorado Denver (US)
- Corresponding author
- McDermott, Michael T.
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 1986-06
- Volume
- 80
- Issue
- 6
- Pages
- 1245-1248
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W2002630469
- Cited by
- 48
- References
- 36
- Citations by year
- 2025: 1 · 2022: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2016: 3 · 2014: 5
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Physical Sciences › Environmental Science › Pollution › Thallium and Germanium Studies
- Keywords
- lithium, thyrotoxicosis, hypothyroidism, bipolar disorder, autoimmune thyroid disease, drug-induced thyroid dysfunction, lithium carbonate
- MeSH terms
- Autoimmune Diseases, Female, Graves Disease, Humans, Hyperthyroidism, Hypothyroidism, Lithium, Middle Aged, Thyroiditis, Autoimmune
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