The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Changes in lipoprotein kinetics during therapy with fenofibrate and other fibric acid derivatives
Abstract
The fibric acid derivatives, including fenofibrate, significantly reduce very low-density lipoprotein triglyceride concentrations by stimulating lipoprotein lipase activity, thereby increasing very low-density lipoprotein catabolism. These agents may also reduce the hepatic secretion of nascent very low-density lipoprotein, but this effect is less consistent. Effects on low-density lipoprotein metabolism appear to depend upon the lipid disorder present before therapy. If hypertriglyceridemia and normal or low low-density lipoprotein levels are present, fibrate therapy is associated with a rise in low-density lipoprotein levels. This is due to a decreased fractional catabolism of low-density lipoprotein from an unusually high clearance to a more normal value. Treating pre-existing hypercholesterolemia usually results in a significant decrease in low-density lipoprotein levels. In this disorder, there is a demonstrable increase in low-density lipoprotein receptor-mediated clearance. It is not known at which site these drugs act to increase low-density lipoprotein receptor function in the latter patients. Some studies suggest that fibrate therapy increases high-density lipoprotein apolipoprotein AI production, but how this occurs has not been defined.
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“although the findings regarding the latter effect of PPARα agonism are less consistent than those regarding increases in the activity of lipoprotein lipase. 17-19”
From Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk (2022) · cites this paper as [17]
Citations
Cites
Mechanism of action of gemfibrozil on lipoprotein metabolism.
Saku, K., Gartside, P. S., Hynd, B. A., & Kashyap, M. L. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111879 · Cited by 182
Influence of Gemfibrozil and Clofibrate on Metabolism of Cholesterol and Plasma Triglycerides in Man
Kesäniemi, Y. A. (1984) · JAMA · doi:10.1001/jama.1984.03340410049031 · Cited by 165
Stewart, J. M., Packard, C. J., Lorimer, A. R., Boag, D. E., & Shepherd, J. (1982) · Atherosclerosis · doi:10.1016/0021-9150(82)90010-7 · Cited by 103
Fenofibrate reduces low density lipoprotein catabolism in hypertriglyceridemic subjects.
Shepherd, J., CASLAKE, M. J., Lorimer, A. R., Vallance, B. D., & Packard, C. J. (1985) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.5.2.162 · Cited by 96
Malmendier, C. L., & Delcroix, C. (1985) · Atherosclerosis · doi:10.1016/0021-9150(85)90095-4 · Cited by 85
Shepherd, J., Packard, C. J., Stewart, J. M., Atmeh, R. F., Clark, R., Boag, D. E., Carr, K., Lorimer, A. R., Ballantyne, D., & Morgan, H. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111643 · Cited by 85
Gemfibrozil Therapy in Primary Hypertriglyceridemia Associated With Coronary Heart Disease
Vega, G. L. (1985) · JAMA · doi:10.1001/jama.253.16.2398 · Cited by 72
Effects of bezafibrate on apolipoprotein B metabolism in type III hyperlipoproteinemic subjects.
Packard, C. J., Clegg, R. J., Dominiczak, M. H., Lorimer, A. R., & Shepherd, J. (1990) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38775-7 · Cited by 54
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Ginsberg, H. N., Packard, C. J., Chapman, M. J., Borén, J., Aguilar-Salinas, C. A., Averna, M., Ference, B. A., Gaudet, D., Hegele, R. A., Kersten, S., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab551 · Cited by 979
“163,164 Guideline-recommended first steps for managing hypertrigly-ceridaemia are diet modification and weight loss.”
BackgroundSelf-citationAoyama, T., Peters, J. M., Iritani, N., Nakajima, T., Furihata, K., Hashimoto, T., & Gonzalez, F. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5678 · Cited by 867
Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk
Das Pradhan, A., Glynn, R. J., Fruchart, J.-C., MacFadyen, J. G., Zaharris, E. S., Everett, B. M., Campbell, S. E., Oshima, R., Amarenco, P., Blom, D. J., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmoa2210645 · Cited by 749
Self-citationCauses and consequences of hypertriglyceridemia
Packard, C. J., Boren, J., & Taskinen, M.-R. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00252 · Cited by 239
“In individuals with initially low plasma triglyceride, fenofibrate therapy caused LDL cholesterol and apoB concentrations to fall by 10–20% (49, 50, 105) due to an increased clearance rate.”
BackgroundBalfour, J. A. B., McTavish, D., & Heel, R. C. (1990) · Drugs · doi:10.2165/00003495-199040020-00007 · Cited by 203
Metadata
- Authors
- Ginsberg, H. N.
- Affiliations
- Columbia University (US)
- Corresponding author
- Ginsberg, Henry N.
- ORCID
- Ginsberg, Henry N.
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 1987-11
- Volume
- 83
- Issue
- 5
- Pages
- 66-70
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W1980196562
- Cited by
- 32
- References
- 8
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2016: 1 · 2014: 1 · 2012: 2
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Keywords
- fenofibrate, fibrates, lipoprotein kinetics, VLDL, low-density lipoprotein, high-density lipoprotein, lipoprotein lipase, hepatic VLDL secretion, hypertriglyceridemia, hypercholesterolemia, apolipoprotein A-I, lipid-lowering therapy
- MeSH terms
- Anticholesteremic Agents, Apolipoproteins, Clofibrate, Humans, Kinetics, Lipoprotein Lipase, Lipoproteins, Lipoproteins, HDL, Lipoproteins, LDL, Lipoproteins, VLDL, Fenofibrate, Propionates
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