The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Mechanisms of nonsteroidal anti-inflammatory drug-induced gastric damage
Open accessAbstract
The effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on the gastric mucosa are well documented. The complex mechanisms of gastric damage, however, are not fully understood. This review examines current knowledge about the normal function of the gastric mucosal barrier; the role of prostaglandins in cytoprotection and repair; the mechanisms by which aspirin and other weak organic acids are absorbed by the stomach; and the subsequent cascade of events--including ion trapping and back diffusion of hydrogen ions--that leads to gastric erosion and bleeding. A hypothesis describing NSAIDs' dual insult on the stomach is advanced.
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Citations
Cites
Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs
VANE, J. R. (1971) · Nature New Biology · doi:10.1038/newbio231232a0 · Cited by 8,605
McMahon, F. G. (1986) · The American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1986.35.673 · Cited by 2,215
Cytoprotection by prostaglandins in rats
Robert, A., Nezamis, J. E., Lancaster, C., & Hanchar, A. J. (1979) · Gastroenterology · doi:10.1016/0016-5085(79)90002-7 · Cited by 1,674
The Glutathione Status of Cells
Kosower, N. S., & Kosower, E. M. (1978) · International Review of Cytology · doi:10.1016/s0074-7696(08)60166-7 · Cited by 1,211
Physiology of the gastrointestinal tract
Dworken, H. J. (1987) · Gastroenterology · doi:10.1016/0016-5085(87)91044-4 · Cited by 643
Physiology of the Digestive Tract.
(1961) · Annals of Internal Medicine · doi:10.7326/0003-4819-55-5-874 · Cited by 578
Mild irritants prevent gastric necrosis through "adaptive cytoprotection" mediated by prostaglandins
Robert, A., Nezamis, J. E., Lancaster, C., Davis, J. P., Field, S. O., & Hanchar, A. J. (1983) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1983.245.1.g113 · Cited by 475
Sulfhydryl Compounds May Mediate Gastric Cytoprotection
Szabo, S., Trier, J. S., & Frankel, P. W. (1981) · Science · doi:10.1126/science.7280691 · Cited by 451
Selective inhibition of prostaglandin production in inflammatory exudates and gastric mucosa
Whittle, B. J. R., Higgs, G. A., Eakins, K. E., Moncada, S., & Vane, J. R. (1980) · Nature · doi:10.1038/284271a0 · Cited by 392
Hawkey, C. J., & Rampton, D. S. (1985) · Gastroenterology · doi:10.1016/0016-5085(85)90225-2 · Cited by 368
Cited by
Sostres, C., Gargallo, C. J., Arroyo, M. T., & Lanas, A. (2010) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2009.11.005 · Cited by 685
Eicosanoids and the gastrointestinal tract
Eberhart, C. E., & Dubois, R. N. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90296-1 · Cited by 414
Hammers, A. L., Sanchez-Ramos, L., & Kaunitz, A. M. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2014.10.1091 · Cited by 101
Intestinal mucosal damage caused by non-steroidal anti-inflammatory drugs: role of bile salts
Petruzzelli, M., Vacca, M., Moschetta, A., Cinzia Sasso, R., Palasciano, G., van Erpecum, K. J., & Portincasa, P. (2007) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2007.01.015 · Cited by 46
Detecting, preventing, and managing patients' alcohol problems.
(1994) · PubMed Central · Cited by 41
Metadata
- Authors
- Schoen, R. T., & Vender, R. J.
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 1989-04
- Volume
- 86
- Issue
- 4
- Pages
- 449-458
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W2007567412
- Cited by
- 332
- References
- 36
- FWCI
- 12.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Schoen, R. T., & Vender, R. J. (1989). Mechanisms of nonsteroidal anti-inflammatory drug-induced gastric damage. The American Journal of Medicine. https://doi.org/10.1016/0002-9343(89)90344-6
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
