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Cited by 104Pregnancy and preeclampsia studiesNeonatal and fetal brain pathologyBirth, Development, and Health

The DOI matches its Crossref record; 19 of the 20 references it cites were found in a registry or an index.

Circulatory responses to prolonged hypoxemia in fetal sheep

Bocking, Alan D., Gagnon, Robert, White, Susan E., Homan, Jacobus, Milne, Kelly M., Richardson, Bryan S.·1988·American Journal of Obstetrics and Gynecology
DOI 10.1016/0002-9378(88)90567-4
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Abstract

Experiments were conducted in 11 chronically catheterized pregnant sheep to determine the distribution of blood flow within the fetus during prolonged (48 hours) hypoxemia secondary to the restriction of uterine blood flow. Uterine blood flow was mechanically restricted with a polytetrafluoroethylene vascular clamp placed around the maternal common internal iliac artery such that mean (+/- SEM) fetal arterial oxygen tension decreased from 23.4 +/- 1.9 to 17.3 +/- 0.8 mm Hg at 1 hour of hypoxemia and remained low for 48 hours. There was an initial increase in fetal arterial carbon dioxide pressure from 48.5 +/- 0.9 mm Hg during the control period to 56.2 +/- 2.3 mm Hg at 1 hour; this parameter subsequently returned to control values, whereas base excess showed a transient decrease. Fetal cerebral, myocardial, and adrenal blood flows were significantly increased at 1, 24, and 48 hours of hypoxemia. In contrast, there was no change in nuchal muscle or renal blood flows with hypoxemia of this magnitude. Cotyledonary blood flow increased transiently by 38% at 1 hour of hypoxemia, but was not changed from control at 24 and 48 hours. These experiments demonstrate that the sheep fetus is able to maintain the normal protective circulatory adjustments seen with acute hypoxemia for up to 48 hours in the absence of progressive metabolic acidemia.

Overview

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Crossref · 10.1016/0002-9378(88)90567-4

Cites

19 of 19 references verified0 citation errors · 0 not checkable

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Citations

Cites

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Research works printed but not linked: 1

  1. Richardson, 1988, Cerebral oxidative metabolism during sustained hypoxemia in fetal sheep, J Dev Physiol

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Metadata

Authors
Bocking, A. D., Gagnon, R., White, S. E., Homan, J., Milne, K. M., & Richardson, B. S.
Affiliations
Western University (CA)
Corresponding author
Bocking, Alan D.
ORCID
Venue
American Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Published
1988-12
Volume
159
Issue
6
Pages
1418-1424
ISSN
0002-9378 (ISSN-L)
DOI
10.1016/0002-9378(88)90567-4
OpenAlex
W2060150502
Cited by
104
References
20
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2020: 3 · 2019: 1 · 2017: 1 · 2016: 4 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 1
FWCI
2.73
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • American Journal of Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and fetal brain pathology
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
fetal hypoxemia, fetal circulation, fetal cerebral blood flow, fetal acidemia, fetal sheep
MeSH terms
Animals, Hypoxia, Blood Circulation, Blood Gas Analysis, Blood Pressure, Cerebrovascular Circulation, Chronic Disease, Female, Fetal Heart, Fetus, Heart Rate, Placenta, Pregnancy, Regional Blood Flow, Sheep

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