Immunohistochemical localization of renin and angiotensin II in human ovaries
Abstract
Ovaries from six women with normal menstrual cycles, a follicle wall biopsy specimen from a gonadotropin-stimulated preovulatory ovary, and a corpus luteum of pregnancy were examined by immunohistochemistry for the presence of immunoreactive renin and angiotensin II. Both antisera densely stained thecal and stromal cells (interstitial complex) and luteal cells. Whereas granulosa cells in developing follicles were either unstained or lightly stained, the heavily luteinized granulosa cells of the preovulatory stimulated follicle were strongly positive for immunoreactive renin and angiotensin II. These anatomic findings are consistent with gonadotropin-stimulated local production of both renin and angiotensin II in the human ovary and support the functional roles proposed for the ovarian renin-angiotensin system in follicle development, ovulation, and luteal function and during pregnancy.
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The activity of intrafollicular AngII may facilitate oocyte maturation, ovulation, and corpus luteum regression.
“Consistenting with previous reports, the activity of intrafollicular AngII may facilitate oocyte maturation [39], ovulation [40], and corpus luteum regression [41].”
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References 22 · Cited by 75
- Authors
- Palumbo, A., Jones, C., Lightman, A., Carcangiu, M. L., DeCherney, A. H., & Naftolin, F.
- Affiliations
- Yale University (US)
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1989-01
- Volume
- 160
- Issue
- 1
- Pages
- 8-14
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W1978223366
- Cited by
- 75
- References
- 22
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2017: 1 · 2016: 1 · 2012: 2
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD22970)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- renin, angiotensin II, human ovary, renin-angiotensin system, theca cells, granulosa cells, luteal cells, corpus luteum, folliculogenesis, ovulation, pregnancy
- MeSH terms
- Adult, Angiotensin II, Corpus Luteum, Female, Chorionic Gonadotropin, Ovarian Follicle, Humans, Immunohistochemistry, Menstrual Cycle, Middle Aged, Ovary, Pregnancy, Renin
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