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Neutrophil attractant/activating peptide-1 / interleukin-8 in term and preterm parturition
Open accessAbstract
The neutrophil is the leukocyte most frequently recruited into the amniotic fluid in cases of microbial invasion of the amniotic cavity. Neutrophil attractant/activating peptide-1/interleukin-8 is a newly identified cytokine that is capable of inducing selective neutrophil chemotaxis and activation. The purpose of this study was to examine the relationship between amniotic fluid concentrations of neutrophil attractant/activating peptide-1/interleukin-8, microbial invasion of the amniotic cavity, and parturition (term and preterm). Amniotic fluid neutrophil attractant/activating peptide-1/interleukin-8 was measured with an immunoassay validated for human amniotic fluid (sensitivity 0.3 ng/ml). Fluid was obtained from women in the following groups: midtrimester (n = 38), term not in labor (n = 38), term in active labor (n = 67), and preterm labor with intact membranes (n = 62). Fluid was cultured for aerobic and anaerobic bacterial and Mycoplasma. Sterile amniotic fluid from most women in the midtrimester of pregnancy and women at term not in labor did not contain immunoreactive neutrophil attractant/activating peptide-1/interleukin-8. Microbial invasion of the amniotic cavity was associated with increased concentrations of neutrophil attractant/activating peptide-1/interleukin-8. The amniotic fluid of women with preterm labor and sterile amniotic fluid who had preterm delivery contained higher neutrophil attractant/activating peptide-1/interleukin-8 levels than did the amniotic fluid of women who responded to tocolysis and had delivery at term. Term parturition is associated with increased concentrations of neutrophil attractant/activating peptide-1/interleukin-8 in the amniotic fluid. We conclude that neutrophil attractant/activating peptide-1/interleukin-8 is part of the host response to microbial invasion of the amniotic cavity and that increased amniotic fluid availability of this cytokine occurs in term and preterm parturition.
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Citations
Cited by
The preterm parturition syndrome
Romero, R., Espinoza, J., Kusanovic, J., Gotsch, F., Hassan, S., Erez, O., Chaiworapongsa, T., & Mazor, M. (2006) · BJOG: An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.01120.x · Cited by 1,419
Self-citationEndocrine and Paracrine Regulation of Birth at Term and Preterm*
Challis, J. R. G., Matthews, S. G., Gibb, W., & Lye, S. J. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.5.0407 · Cited by 995
Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance
Kim, C. J., Romero, R., Chaemsaithong, P., Chaiyasit, N., Yoon, B. H., & Kim, Y. M. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.08.040 · Cited by 910
Self-citationA fetal systemic inflammatory response is followed by the spontaneous onset of preterm parturition
Romero, R., Gomez, R., Ghezzi, F., Yoon, B. H., Mazor, M., Edwin, S. S., & Berry, S. M. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70271-6 · Cited by 546
Self-citationRomero, R., Miranda, J., Chaiworapongsa, T., Korzeniewski, S. J., Chaemsaithong, P., Gotsch, F., Dong, Z., Ahmed, A. I., Yoon, B. H., Hassan, S. S., et al. (2014) · American Journal of Reproductive Immunology · doi:10.1111/aji.12296 · Cited by 485
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Metadata
- Authors
- Romero, R., Ceska, M., Avila, C., Mazor, M., Behnke, E., & Lindley, I.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 1991-10
- Volume
- 165
- Issue
- 4
- Pages
- 813-820
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W1971351331
- Cited by
- 344
- References
- 0
- FWCI
- 10.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Romero, R., Ceska, M., Avila, C., Mazor, M., Behnke, E., & Lindley, I. (1991). Neutrophil attractant/activating peptide-1 / interleukin-8 in term and preterm parturition. American Journal of Obstetrics and Gynecology. https://doi.org/10.1016/0002-9378(91)90422-n
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