Distribution, Subcellular Localization, and Product Inhibition of Dihydroorotate Oxidation in the Rat
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The inhibition of complexes III and IV affects the dihydroorotate dehydrogenase pathway involved in ubiquinone-mediated de novo pyrimidine synthesis.
“The inhibition of complexes III and IV affects the dihydroorotate dehydrogenase pathway involved in ubiquinone-mediated de novo pyrimidine synthesis [49,50,51].”
From Proliferating Astrocytes in Primary Culture Do Not Depend upon Mitochondrial Respiratory Complex I Activity or Oxidative Phosphorylation (2023) · cites this paper as [49]
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Silva, E. A., Dalla Costa, A. P., Ruas, J. S., Siqueira-Santos, E. S., Francisco, A., & Castilho, R. F. (2023) · Cells · doi:10.3390/cells12050683 · Cited by 5 · see citing works
- Authors
- Kennedy, J.
- Affiliations
- Columbia University (US)
- Corresponding author
- Kennedy, James
- Venue
- Archives of Biochemistry and Biophysics
- Publisher
- Elsevier BV
- Published
- 1973-08
- Volume
- 157
- Issue
- 2
- Pages
- 369-373
- ISSN
- 0003-9861 (ISSN-L)
- OpenAlex
- W2041625394
- Cited by
- 38
- References
- 0
- Citations by year
- 2023: 1 · 2019: 1 · 2013: 1
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Biochemistry and Biophysics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
- Health Sciences › Medicine › Nephrology › Gout, Hyperuricemia, Uric Acid
- Keywords
- dihydroorotate dehydrogenase, orotic acid, product inhibition, competitive inhibition, pyrimidine synthesis, subcellular localization, mitochondrial enzymes, tissue distribution, rats
- MeSH terms
- Adipose Tissue, Animals, Brain, Cell Fractionation, Intestine, Small, Kidney, Kinetics, Liver, Lung, Male, Mitochondria, Liver, Muscles, Myocardium, Organ Specificity, Orotic Acid, Oxidoreductases, Spectrophotometry, Ultraviolet, Spleen, Stomach, Subcellular Fractions, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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