X-ray diffraction evidence for myelin disorder in brain from humans with alzheimer's disease
Abstract
Wide-angle X-ray diffraction studies revealed that the lipid phase transition temperature of myelin from brain tissue of humans with Alzheimer's disease was about 12 degrees C lower than that of normal age-matched controls, indicating differences in the physical organization of the myelin lipid bilayer. Elevated levels of malondialdehyde and conjugated diene were found in brain tissue from humans with Alzheimer's disease, indicating an increased amount of lipid peroxidation over the controls. An increase in myelin disorder and in lipid peroxidation can both be correlated with aging in human brain, but the changes in myelin from humans with Alzheimer's disease are more pronounced than in normal aging. These changes might represent severe or accelerated aging.
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Dysfunction of oligodendrocytes and myelin breakdown may be early events in AD.
“Dysfunction of oligodendrocytes and myelin breakdown may be early events in AD72–75.”
From Integrated multimodal cell atlas of Alzheimer’s disease (2024) · cites this paper as [72]
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References 17 · Cited by 87
- Authors
- Chia, L. S., Thompson, J. E., & Moscarello, M. A.
- Affiliations
- Hospital for Sick Children (CA)
- Venue
- Biochimica et Biophysica Acta (BBA) - Biomembranes
- Publisher
- Elsevier BV
- Published
- 1984-09
- Volume
- 775
- Issue
- 3
- Pages
- 308-312
- ISSN
- 0005-2736 (ISSN-L)
- OpenAlex
- W2057196062
- Cited by
- 87
- References
- 17
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2020: 1 · 2018: 1 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 1
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Biomembranes (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, myelin, lipid phase transition temperature, lipid peroxidation, malondialdehyde, conjugated dienes, brain aging, accelerated aging, human brain tissue
- MeSH terms
- Aging, Alzheimer Disease, Brain, Crystallography, Humans, Lipid Peroxides, Malondialdehyde, Membrane Fluidity, Myelin Proteins, X-Ray Diffraction
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