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Cited by 27Cholesterol and Lipid MetabolismPlant biochemistry and biosynthesisSteroid Chemistry and Biochemistry

Squalene epoxidase and oxidosqualene lanosterol-cyclase activities in cholesterogenic and non-cholesterogenic tissues

Astruc, M., Tabacik, C., Descomps, B., de Paulet, A.Crastes·1977·Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
DOI 10.1016/0005-2760(77)90056-x
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Abstract

Squalene epoxidase and oxidosqualene lanosterol-cyclase activities have been studied in normal mammalian cholesterogenic and non-cholesterogenic tissues. This paper describes the kinetic conditions of measurement of these two enzymatic acitivities and their results. Oxidosqualene lanosterol-cyclase is a widespread enzyme, present in all cholesterogenic and non-cholesterogenic tissues. However, the level of squalene epoxidase is very low in non-cholesterogenic tissues. However, the level of squalene epoxidase is very low in non-cholesterogenic tissues. The effects of subcellular fractionizing and of the physico-chemical state of squalene incubated in vitro on squalene epoxidase activity are discussed.

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Crossref · 10.1016/0005-2760(77)90056-x

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1 of 1 references verified0 citation errors · 0 not checkable

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Authors
Astruc, M., Tabacik, C., Descomps, B., & de Paulet, A. C.
Affiliations
Inserm (FR)
Venue
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
Publisher
Elsevier BV
Published
1977-04
Volume
487
Issue
1
Pages
204-211
ISSN
0005-2760 (ISSN-L)
DOI
10.1016/0005-2760(77)90056-x
OpenAlex
W2094539543
Cited by
27
References
1
Citations by year
2024: 1 · 2023: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 1 · 2013: 1 · 2012: 2
FWCI
0.72
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
Keywords
squalene epoxidase, cholesterol biosynthesis, enzyme kinetics, subcellular fractionation
MeSH terms
Animals, Brain, Cholesterol, Cytosol, Ethers, Cyclic, Female, Humans, Isomerases, Kidney, Kinetics, Lanosterol, Liver, Lung, Microsomes, Muscles, Organ Specificity, Oxygenases, Placenta, Pregnancy, Squalene, Subcellular Fractions, Rats

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