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Lipoprotein lipase in liver. Release by heparin and immunocytochemical localization

Vilaró, Senén, Ramírez, Ignasi, Bengtsson-Olivecrona, Gunilla, Olivecrona, Thomas, Llobera, Miquel·1988·Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
DOI 10.1016/0005-2760(88)90021-5
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Abstract

We have previously demonstrated that infusion of Intralipid to rats causes a pronounced increase of the lipoprotein lipase activity in the liver. In this paper we study where in the liver this lipoprotein lipase is located. When isolated livers from Intralipid-treated rats were perfused with heparin, substantial amounts of lipoprotein lipase were released into the perfusate. The identity of the lipase activity was demonstrated by specific inhibition with antisera to lipoprotein lipase, and to hepatic lipase, respectively, and by separation of the two lipase activities by chromatography on heparin-Sepharose. We have also studied the localization of both enzymes by an immunostaining procedure based on post-embedding incubation of ultrathin tissue sections with specific antibodies which were then visualized using protein A-colloidal gold complexes. There was no marked difference in localization for the two enzymes which were both seen at the luminal side of endothelial cells, at the interdigitations of the space of Disse and inside both hepatocytes and endothelial cells. Thus, lipoprotein lipase is present in the liver in positions similar to where the functional pool of hepatic lipase is located and analogous to where lipoprotein lipase is found in extrahepatic tissues. These results raise the possibility that the enzyme has a functional role in the liver.

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  • Reduced sulfation of heparan chains could also decrease the pool of apoE/Lpl/HL associated with the hepatocyte plasma membrane, which may act as a reservoir for enriching TRLs with these ligands or as molecular bridges between lipoproteins and their receptors.

    “Reduced sulfation of heparan chains could also decrease the pool of apoE/Lpl/HL associated with the hepatocyte plasma membrane (9, 10, 59), which may act as a reservoir for enriching TRLs with these ligands or as molecular bridges between lipoproteins their receptors.”

    From Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members (2007) · cites this paper as [9]

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Research works printed but not linked: 36

  1. Assman, 1973, J. Biol. Chem., 248, 1992, 10.1016/S0021-9258(19)44177-X · DOI
  2. Miller Ben Avram, 1986, 83, 4185
  3. Greten, 1972, FEBS Lett., 21, 306, 10.1016/0014-5793(72)80647-1 · DOI
  4. Jansen, 1980, Trends Biochem. Sci., 265, 10.1016/0968-0004(80)90033-X · DOI
  5. Cryer, 1981, Int. J. Biochem., 13, 525, 10.1016/0020-711X(81)90177-4 · DOI
  6. Kuusi, 1979, FEBS Lett., 104, 384, 10.1016/0014-5793(79)80858-3 · DOI
  7. Robinson, 1970, Comp. Biochem., 18, 51
  8. Kuusi, 1979, Biochem. J., 181, 245, 10.1042/bj1810245 · DOI
  9. Pedersen, 1983, J. Lipid Res., 24, 512, 10.1016/S0022-2275(20)37956-6 · DOI
  10. Jonasson, 1984, Atherosclerosis, 51, 313, 10.1016/0021-9150(84)90179-5 · DOI
  11. Bensadoun, 1977, J. Lipid Res., 18, 768, 10.1016/S0022-2275(20)41595-0 · DOI
  12. Llobera, 1979, Biochem. Biophys. Res. Commun., 91, 272, 10.1016/0006-291X(79)90613-2 · DOI
  13. Jensen, 1980, J. Biol. Chem., 255, 11141, 10.1016/S0021-9258(19)70267-1 · DOI
  14. Paterniti, 1983, Science, 221, 167, 10.1126/science.6857276 · DOI
  15. Black, 1983, Biochem. Soc. Trans., 11, 708, 10.1042/bst0110708 · DOI
  16. Knobler, 1984, Biochim. Biophys. Acta, 782, 363, 10.1016/0005-2760(84)90087-0 · DOI
  17. Masuno, 1984, J. Lipid Res., 25, 419, 10.1016/S0022-2275(20)37793-2 · DOI
  18. Testar, 1985, Biochem. Soc. Trans., 13, 134, 10.1042/bst0130134 · DOI
  19. Olivecrona, 1985, J. Biol. Chem., 260, 2552, 10.1016/S0021-9258(18)89587-4 · DOI
  20. Peterson, 1985, Biochim. Biophys. Acta, 837, 262, 10.1016/0005-2760(85)90049-9 · DOI
  21. Vilaró, 1986, Biochem. J., 236, 273, 10.1042/bj2360273 · DOI
  22. Wallinder, 1979, Biochim. Biophys. Acta, 575, 166, 10.1016/0005-2760(79)90142-5 · DOI
  23. Wallinder, 1984, Biochim. Biophys. Acta, 769, 513, 10.1016/0005-2760(84)90181-4 · DOI
  24. Olivecrona, 1983, Biochim. Biophys. Acta, 752, 38, 10.1016/0005-2760(83)90230-8 · DOI
  25. Meijer, 1981, Methods Enzymol., 77, 81, 10.1016/S0076-6879(81)77013-7 · DOI
  26. Leibovitz, 1963, Am. J. Hygiene, 78, 173
  27. Ehnholm, 1975, J. Biol. Chem., 250, 6756, 10.1016/S0021-9258(19)40996-4 · DOI
  28. Frens, 1973, Nat. Phys. Sci., 241, 20, 10.1038/physci241020a0 · DOI
  29. Jansen, 1977, Biochim. Biophys. Acta, 77, 861
  30. Kuusi, 1979, FEBS Lett., 98, 314, 10.1016/0014-5793(79)80207-0 · DOI
  31. Jensen, 1981, Anal. Biochem., 113, 246, 10.1016/0003-2697(81)90073-7 · DOI
  32. Chuang, 1985, Biochim. Biophys. Acta, 833, 69, 10.1016/0005-2760(85)90254-1 · DOI
  33. Reina, 1985, Biochem. Soc. Trans., 13, 868, 10.1042/bst0130868 · DOI
  34. Bengtsson, 1977, Biochem. J., 167, 109, 10.1042/bj1670109 · DOI
  35. Pedersen, 1981, Biochim. Biophys. Acta, 666, 191, 10.1016/0005-2760(81)90105-3 · DOI
  36. Vilaró, 1987, Biochem. J.

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Metadata

Authors
Vilaró, S., Ramírez, I., Bengtsson-Olivecrona, G., Olivecrona, T., & Llobera, M.
Venue
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
Publisher
Elsevier BV
Published
1988-03
Volume
959
Issue
2
Pages
106-117
ISSN
0005-2760
DOI
10.1016/0005-2760(88)90021-5
Cited by
25
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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