Partial removal of bound transfer RNA from polysomes engaged in protein synthesis in vitro after addition of tetracycline
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Tetracyclines inhibit protein synthesis by blocking the binding of aminoacylated tRNA to the A site.
“where they inhibit protein synthesis by blocking the binding of aminoacylated tRNA (aa-tRNA) to the A site (Maxwell 1967; Geigenmuller and Nierhaus 1986”
From The Structural Basis for the Action of the Antibiotics Tetracycline, Pactamycin, and Hygromycin B on the 30S Ribosomal Subunit (2000) · cites this paper as Maxwell 1967
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References 20 · Cited by 37
- Authors
- Maxwell, I. H.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Maxwell, I.H.
- Venue
- Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis
- Publisher
- Elsevier BV
- Published
- 1967-04
- Volume
- 138
- Issue
- 2
- Pages
- 337-346
- ISSN
- 0005-2787 (ISSN-L)
- OpenAlex
- W2034809674
- Cited by
- 37
- References
- 20
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 1 · 2017: 1 · 2016: 1 · 2013: 2 · 2012: 1
- FWCI
- 1.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
- Keywords
- tetracycline, tRNA, polysomes, ribosome binding, protein synthesis inhibition, aminoacyl-tRNA, ribosome-mRNA complex, Bacillus megaterium, Escherichia coli, cell-free protein synthesis
- MeSH terms
- Bacillus megaterium, Bacterial Proteins, Carbon Isotopes, Escherichia coli, Peptide Biosynthesis, Phosphorus Isotopes, Protein Hydrolysates, Ribosomes, RNA, Bacterial, RNA, Transfer, Tetracycline, Ultracentrifugation, Eukaryota
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