The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Stoichiometry of the reaction of oxyhemoglobin with nitrite
Abstract
During the reaction of oxyhemoglobin (HbO2) with nitrite, the concentration of residual nitrite, nitrate, oxygen, and methemoglobin (Hb+) was determined successively. The results obtained at various pH values indicate the following stoichiometry for the overall reaction: 4HbO2 + 4NO2- 4H+ leads to 4Hb+ + 4NO3- + O2 + 2H2 O (Hb denotes hemoglobin monomer). NO2- binds with methemoglobin noncooperatively with a binding constant of 340 M-1 at pH 7.4 and 25 degrees C. Thus, the major part of Hb+ produced is aquomethemoglobin, not methemoglobin nitrite, when less than 2 equivalents of nitrite is used for the oxidation.
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“the high concentrations of oxyhemoglobin usually found in the bloodstream can easily convert nitrite to nitrate [47,48].”
From Sodium nitrite downregulates vascular NADPH oxidase and exerts antihypertensive effects in hypertension (2011) · cites this paper as [48]
Citations
Cites
THE REACTION OF HEMOGLOBIN WITH NITRITE
Greenberg, L. A., Lester, D., & Haggard, H. W. (1943) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)44941-1 · Cited by 49
�ber die Umsetzung zwischen Nitrit und H�moglobin
Jung, F., & Remmer, H. (1949) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00245806 · Cited by 37
Studien über Methämoglobinbildung
Meier, R. (1925) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf01862083 · Cited by 37
Simple and Sensitive Procedure for Determining Nitrate and Nitrite in Mixtures in Biological Fluids
Wegner, T. N. (1972) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(72)85550-4 · Cited by 19
Evidence for an irreversible reaction between nitrite and human methemoglobin
Uchida, H., & Klapper, M. H. (1970) · Biochimica et Biophysica Acta (BBA) - Protein Structure · doi:10.1016/0005-2795(70)90236-9 · Cited by 14
Research works printed but not linked: 5
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- Kakizaki, 1965, Seikagaku (in Jap.), 37, 14
- Benesch, 1968, 59, 526
- Roy, 1969, Acta Biol. Med. Ger., 22, 445
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Cited by
Sorted by citations
Stuehr, D. J., & Nathan, C. F. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.5.1543 · Cited by 1,744
Feelisch, M., & Noack, E. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90493-6 · Cited by 887
Ignarro, L. J., Fukuto, J. M., Griscavage, J. M., Rogers, N. E., & Byrns, R. E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.8103 · Cited by 856
Nitric oxide metabolism and breakdown
Kelm, M. (1999) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(99)00020-1 · Cited by 673
Biochemistry of Peroxynitrite and Protein Tyrosine Nitration
Ferrer‐Sueta, G., Campolo, N., Trujillo, M., Bartesaghi, S., Carballal, S., Romero, N., Álvarez, B., & Radí, R. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00568 · Cited by 653
Metadata
- Authors
- Kosaka, H., Imaizumi, K., Imai, K., & Tyuma, I.
- Affiliations
- The University of Osaka (JP)
- ORCID
- Imaizumi, Kazuhiko
- Venue
- Biochimica et Biophysica Acta (BBA) - Protein Structure
- Publisher
- Elsevier BV
- Published
- 1979-11
- Volume
- 581
- Issue
- 1
- Pages
- 184-188
- ISSN
- 0005-2795 (ISSN-L)
- OpenAlex
- W2077180688
- Cited by
- 139
- References
- 5
- Citations by year
- 2024: 1 · 2022: 1 · 2020: 1 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 3
- FWCI
- 3.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Protein Structure (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Interaction Studies and Fluorescence Analysis
- Keywords
- oxyhemoglobin, nitrite, methemoglobin, hemoglobin oxidation, reaction stoichiometry, non-cooperative binding, pH dependence, nitrate
- MeSH terms
- Hemoglobin A, Humans, Hydrogen-Ion Concentration, Kinetics, Methemoglobin, Nitrites, Oxyhemoglobins
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