Characterization of a cytochrome P450 deficient mutant of Candidaalbicans
Abstract
A previously described Candida albicans nystatin resistant mutant blocked in 14 alpha-demethylation of lanosterol was shown to also lack all traces of cytochrome P450 as determined by carbon monoxide difference spectra. This strain does not require ergosterol for growth and reverted to an ergosterol producing, cytochrome P450 containing strain indicating no other lesions. Cytochrome P450 mutants described in Saccharomyces cerevisiae are auxotrophic for ergosterol or contain a second mutation in 5,6 desaturation of the sterol B ring. These results suggest that a cytochrome P450 lesion in these yeasts have different phenotypes and may reflect different sterol requirements for the two organisms.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
C. albicans can survive the inhibition of ergosterol synthesis.
“Although C. albicans can survive the inhibition of ergosterol synthesis,”
From The synthesis, regulation, and functions of sterols in<i>Candida albicans</i>: Well-known but still lots to learn (2016) · cites this paper as [39]
The citation lists haven’t been fetched yet
References 17 · Cited by 34
- Authors
- Bard, M., Lees, N. D., Barbuch, R. J., & Sanglard, D.
- Affiliations
- Indiana University – Purdue University Indianapolis (US)
- University of Cincinnati (US)
- ORCID
- Sanglard, D.
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1987-09
- Volume
- 147
- Issue
- 2
- Pages
- 794-800
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W18560267
- Cited by
- 34
- References
- 17
- Citations by year
- 2017: 1 · 2016: 1 · 2013: 1
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Keywords
- Candida albicans, cytochrome P450, nystatin resistance, lanosterol, ergosterol, sterol biosynthesis, auxotrophy
- MeSH terms
- Candida albicans, Cytochrome P-450 Enzyme System, Drug Resistance, Microbial, Ergosterol, Lanosterol, Mutation, Nystatin, Phenotype, Saccharomyces cerevisiae, Sterols
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
