Cited by 370Protease and Inhibitor MechanismsNeutrophil, Myeloperoxidase and Oxidative MechanismsCoagulation, Bradykinin, Polyphosphates, and Angioedema

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ONO-5046, a novel inhibitor of human neutrophil elastase

Kawabata, Kazuhito, Suzuki, Mayumi, Sugitani, Masafumi, Imaki, Katsuhiro, Toda, Masaaki, Miyamoto, Tsumoru·1991·Biochemical and Biophysical Research Communications

DOI 10.1016/0006-291x(91)91862-7

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Abstract

ONO-5046, N-[2-[4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino] aminoacetic acid, competitively inhibited human neutrophil elastase (IC50 = 0.044 microM, Ki = 0.2 microM). It also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse. However, ONO-5046 did not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 microM. In in vivo studies, ONO-5046 suppressed lung hemorrhage in hamster (ID50 = 82 micrograms/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase.

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Elastolytic Activity in Pulmonary Lavage Fluid from Patients with Adult Respiratory-Distress Syndrome
Lee, C. T., Fein, A. M., Lippmann, M. L., Holtzman, H., Kimbel, P., & Weinbaum, G. (1981) · New England Journal of Medicine · doi:10.1056/nejm198101223040402 · Cited by 516
Proteolysis by Neutrophils
Campbell, E. J., Senior, R. M., McDonald, J. A., Cox, D. L., Greco, J. M., & Landis, J. A. (1982) · Journal of Clinical Investigation · doi:10.1172/jci110681 · Cited by 243
Purification and specificity of pancreatic elastase
Naughton, M. A., & Sanger, F. (1961) · Biochemical Journal · doi:10.1042/bj0780156 · Cited by 206
Physiology and Pathophysiology of Neutral Proteinases of Human Granulocytes
HAVEMANN, K., & Gramse, M. (1984) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-9355-3_1 · Cited by 132
Pericellular proteolysis by neutrophils in the presence of proteinase inhibitors: effects of substrate opsonization.
Campbell, E. J., & Campbell, M. A. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.106.3.667 · Cited by 125
Elastase-mediated fibrinogenolysis by chemoattractant-stimulated neutrophils occurs in the presence of physiologic concentrations of antiproteinases.
Weitz, J. I., Huang, A. J. Y., Landman, S. L., Nicholson, S., & Silverstein, S. C. (1987) · The Journal of Experimental Medicine · doi:10.1084/jem.166.6.1836 · Cited by 120
Neutrophil-mediated solubilization of the subendothelial matrix: oxidative and nonoxidative mechanisms of proteolysis used by normal and chronic granulomatous disease phagocytes.
Weiss, S. J., Curnutte, J. T., & REGIANI, S. R. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.136.2.636 · Cited by 112
Rheumatoid arthritis
Weissmann, G., & Korchak, H. M. (1984) · Inflammation · doi:10.1007/bf00915708 · Cited by 78
A new class of inhibitors of human leucocyte elastase
Hassall, C. H., Johnson, W. H., Kennedy, A. J., & Roberts, N. A. (1985) · FEBS Letters · doi:10.1016/0014-5793(85)80776-6 · Cited by 37
A novel method of isolation and some characteristic properties of human pancreatic elastases
Fujimoto, K.-I., Ogawa, M., Saito, N., Kōsaki, G., Minamiura, N., & Yamamoto, T. (1980) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(80)90300-9 · Cited by 21

Show all 13 references

Research works printed but not linked: 7

Carp, 1982, 79, 2041
Jochum, 1986, Behring Inst. Mitt, 79, 121
Krell, 1988, FASEB Journal, 2, A346
Trainor, 1987, TIPS, 8, 303
Levine, 1976, Am. Rev. Respir. Dis, 113, 25
Matsuoka, 1989, Japan J. Pharmacol, 51, 455, 10.1254/jjp.51.455 · DOI
Soskel, 1986, Am. Rev. Respir. Dis, 133, 635

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Osaka, D., Shibata, Y., Kanouchi, K., Nishiwaki, M., Kimura, T., Kishi, H., Abe, S., Inoue, S., Tokairin, Y., Igarashi, A., et al. (2011) · International Journal of Medical Sciences · doi:10.7150/ijms.8.302 · Cited by 25
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Ito, H., Nakayama, H., Yokose, T., & Yamada, K. (2014) · Asian Cardiovascular and Thoracic Annals · doi:10.1177/0218492314526187 · Cited by 21
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Ahmad, S., Tyrrell, J., Walton, W. G., Tripathy, A., Redinbo, M. R., & Tarran, R. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00975-16 · Cited by 21
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Hayashida, K., Fujishima, S., Sasao, K., Orita, T., Toyoda, Y., Kitano, M., & Hori, S. (2011) · Shock · doi:10.1097/shk.0b013e318225acc3 · Cited by 21
Reversible Ketomethylene-Based Inhibitors of Human Neutrophil Proteinase 3
Budnjo, A., Narawane, S., Grauffel, C., Schillinger, A.-S., Fossen, T., Reuter, N., & Haug, B. E. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm500782s · Cited by 20
Biochemical properties and primary structure of elastase inhibitor AFUEI from Aspergillus fumigatus
Okumura, Y., Matsui, T., Ogawa, K., Uchiya, K., & Nikai, T. (2008) · Journal of Medical Microbiology · doi:10.1099/jmm.0.47789-0 · Cited by 20
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Kwon, A.-H., & Qiu, Z. (2007) · British journal of surgery · doi:10.1002/bjs.5625 · Cited by 20
Mitogen-activated protein kinase involves neutrophil elastase-induced morphological changes in human bronchial epithelial cells
川上, 雄., Maruoka, S., Gon, Y., Matsumoto, K., Takeshita, I., & Horie, T. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00080-6 · Cited by 19

Authors: Kawabata, K., Suzuki, M., Sugitani, M., Imaki, K., Toda, M., & Miyamoto, T.
Affiliations: Ono Pharmaceutical (Japan) (JP)
ORCID: Suzuki, Mayumi
Venue: Biochemical and Biophysical Research Communications
Publisher: Elsevier BV
Published: 1991-06
Volume: 177
Issue: 2
Pages: 814-820
ISSN: 0006-291X (ISSN-L)
DOI: 10.1016/0006-291x(91)91862-7
OpenAlex: W2039697569
Cited by: 359
References: 13
Citations by year: 2026: 8 · 2025: 6 · 2024: 11 · 2023: 10 · 2022: 10 · 2021: 9 · 2020: 7 · 2019: 9 · 2018: 7 · 2017: 8 · 2016: 8 · 2015: 18 · 2014: 8 · 2013: 11 · 2012: 12
FWCI: 2.09
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochemical and Biophysical Research Communications (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Health Sciences › Medicine › Hematology › Coagulation, Bradykinin, Polyphosphates, and Angioedema
Keywords: ONO-5046, human neutrophil elastase, leukocyte elastase, elastase inhibitors, competitive inhibition, serine protease inhibition, pulmonary hemorrhage
MeSH terms: Animals, Binding, Competitive, Capillary Permeability, Glycine, Guinea Pigs, Cricetinae, Hemorrhage, Humans, Lung Diseases, Male, Mesocricetus, Neutrophils, Pancreatic Elastase, Rabbits, Skin Diseases, Sulfonamides, Mice, Rats

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ONO-5046, a novel inhibitor of human neutrophil elastase

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