The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
Overview
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Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The inhibition constant (K i ) value for the reversal of DHT action by hydroxyflutamide was estimated at 39 nm (233), in agreement with the affinity of the antagonist for the AR (227).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [233]
Citations
Cites
Cleland, W. W. (1963) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(63)91800-6 · Cited by 2,092
The kinetics of enzyme-catalyzed reactions with two or more substrates or products
Cleland, W. W. (1963) · Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects · doi:10.1016/0926-6569(63)90211-6 · Cited by 1,915
Enzyme and metabolic inhibitors
Webb, J. L. (1963) · Academic Press eBooks · doi:10.5962/bhl.title.7320 · Cited by 1,529
The Biochemistry of Folic Acid and Related Pteridines.
(1970) · Annals of Internal Medicine · doi:10.7326/0003-4819-72-1-153_1 · Cited by 1,027
Cleland, W. W. (1963) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(63)91815-8 · Cited by 867
The kinetics of enzyme-catalyzed reactions with two or more substrates or products
Cleland, W. W. (1963) · Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects · doi:10.1016/0926-6569(63)90227-x · Cited by 851
The kinetics of enzyme-catalyzed reactions with two or more substrates or products
Cleland, W. W. (1963) · Biochimica et Biophysica Acta (BBA) - Specialized Section on Enzymological Subjects · doi:10.1016/0926-6569(63)90226-8 · Cited by 790
ENZYME AND METABOLIC INHIBITORS
Fisher, R. B. (1964) · Quarterly Journal of Experimental Physiology and Cognate Medical Sciences · doi:10.1113/expphysiol.1964.sp001725 · Cited by 552
Cleland, W. W. (1963) · Biochimica et Biophysica Acta · doi:10.1016/0006-3002(63)91816-x · Cited by 519
Design of Active-Site-Directed Irreversible Enzyme Inhibitors.
Burger, A. (1967) · Journal of Medicinal Chemistry · doi:10.1021/jm00318a065 · Cited by 389
Cha, S. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81739-8 · Cited by 339
Erythrocytic Nucleoside Diphosphokinase
Mourad, N., & Parks, R. E. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)96912-7 · Cited by 188
Kinetic and Photochemical Studies of 3-N-Methyl-5-iodo-2′-deoxyuridine
Voytek, P. E., CHANG, P. K., & Prusoff, W. H. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45713-x · Cited by 17
Self-citation
Cited by
Sorted by citations
An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19
Owen, D. R., Allerton, C. M. N., Anderson, A. S., Aschenbrenner, L., Avery, M., Berritt, S., Boras, B., Cardin, R. D., Carlo, A., Coffman, K. J., et al. (2021) · Science · doi:10.1126/science.abl4784 · Cited by 2,033
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
McCabe, M. T., Ott, H. M., Ganji, G., Korenchuk, S., Thompson, C., Van Aller, G. S., Liu, Y., Graves, A. P., III, A. D. P., Diaz, E., et al. (2012) · Nature · doi:10.1038/nature11606 · Cited by 1,786
Jasmonate perception by inositol-phosphate-potentiated COI1–JAZ co-receptor
Sheard, L. B., Tan, X., Mao, H., Withers, J., Ben-Nissan, G., Hinds, T. R., Kobayashi, Y., Hsu, F.-F., Sharon, M., Browse, J., et al. (2010) · Nature · doi:10.1038/nature09430 · Cited by 1,497
Regulation of serotonin-2C receptor G-protein coupling by RNA editing
Burns, C. M., Chu, H., Rueter, S. M., Hutchinson, L. K., Canton, H., Sanders-Bush, E., & Emeson, R. B. (1997) · Nature · doi:10.1038/387303a0 · Cited by 1,010
Imaging Synaptic Neurotransmission with in Vivo Binding Competition Techniques: A Critical Review
Laruelle, M. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200003000-00001 · Cited by 944
Metadata
- Authors
- Yung-Chi, C., & Prusoff, W. H.
- Affiliations
- Yale University (US)
- Venue
- Biochemical Pharmacology
- Publisher
- Elsevier BV
- Published
- 1973-12
- Volume
- 22
- Issue
- 23
- Pages
- 3099-3108
- ISSN
- 0006-2952 (ISSN-L)
- OpenAlex
- W2074631079
- Cited by
- 12,922
- References
- 13
- Citations by year
- 2026: 202 · 2025: 242 · 2024: 247 · 2023: 218 · 2022: 258 · 2021: 298 · 2020: 274 · 2019: 279 · 2018: 295 · 2017: 326 · 2016: 328 · 2015: 357 · 2014: 347 · 2013: 359 · 2012: 371
- FWCI
- 4.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Enzyme function and inhibition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
- Physical Sciences › Chemistry › Physical and Theoretical Chemistry › thermodynamics and calorimetric analyses
- Keywords
- enzyme inhibition, inhibition constant, competitive inhibition, non-competitive inhibition, uncompetitive inhibition, inhibition kinetics, substrate concentration dependence
- MeSH terms
- Binding, Competitive, Enzyme Inhibitors, Kinetics, Mathematics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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