The uptake and intracellular accumulation of aminoglycoside antibiotics in lysosomes of cultured rat fibroblasts
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Aminoglycosides largely accumulate in the lysosomes and are likely to be ineffective against cytosolic pathogens.
“aminoglycosides largely accumulate in the lysosomes and are likely to be ineffective against cytosolic pathogens 64 .”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [64]
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References 61 · Cited by 157
- Authors
- Tulkens, P., & Trouet, A.
- Affiliations
- UCLouvain (BE)
- ORCID
- Tulkens, Paul
- Venue
- Biochemical Pharmacology
- Publisher
- Elsevier BV
- Published
- 1978-02
- Volume
- 27
- Issue
- 4
- Pages
- 415-424
- ISSN
- 0006-2952 (ISSN-L)
- OpenAlex
- W1969311276
- Cited by
- 157
- References
- 61
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 1 · 2021: 2 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 6 · 2015: 5 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 5.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Antibiotics Pharmacokinetics and Efficacy
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- aminoglycosides, lysosomes, drug uptake, intracellular accumulation, lysosomal enzymes, streptomycin, dihydrostreptomycin, gentamicin, kanamycin, amikacin, fibroblasts, subcellular localization, intracellular bacteria, phagosome, lysosomal pH
- MeSH terms
- Aminoglycosides, Animals, Anti-Bacterial Agents, Blood Physiological Phenomena, Cells, Cultured, Fibroblasts, Hydrogen-Ion Concentration, Kinetics, Lysosomes, Streptomycin, Subcellular Fractions, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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