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Cited by 472Neurotransmitter Receptor Influence on BehaviorNeuroscience and Music PerceptionNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 142 of the 148 references it cites were found in a registry or an index.

Intensity dependence of auditory evoked potentials as an indicator of central serotonergic neurotransmission: A new hypothesis

Hegerl, Ulrich, Juckel, Georg·1993·Biological Psychiatry
DOI 10.1016/0006-3223(93)90137-3
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Abstract

Because of the increasing importance of the central serotonergic neurotransmission for pathogenetic concepts and its role as a target of pharmacotherapeutic interventions in psychiatry, reliable indicators of this system are needed. It is proposed that the stimulus intensity dependence of auditory evoked N1/P2-component, which is probably modulated by cortical serotonergic innervation, may be a useful and noninvasive indicator of behaviorally relevant aspects of serotonergic activity. Converging evidence from our own studies as well as from the literature suggests that a pronounced intensity dependence of auditory evoked N1/P2-component reflects low central serotonergic neurotransmission. Recent findings concerning general functional aspects of the brain serotonin system reveal that this system is well qualified for adjusting individual levels of sensory processing ("set the tone"), especially in the primary auditory cortex in which the N1/P2-component is mainly generated. Dipole source analysis represents an important methodological advance in this context because it allows the separation of N1/P2-subcomponents generated in the primary auditory cortex from those generated in secondary auditory areas.

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Show all 148 references

Research works printed but not linked: 5

  1. Hegerl, 1991, Auditory evoked potentials and clinical response to antidepressive treatment with fluvoxamine, Biol Psychiatry, 29, 602S
  2. Lukas, 1987, Human augmenting-reducing and sensation seeking, Psychophysiology, 19, 333
  3. Odagaki, 1992, Lithium and serotonergic neural transmission: A review of pharmacological and biochemical aspects in animal studies, Lithium, 3, 95
  4. Sutter, 1991, Topography of intensity encoding by single neurons in cat primary auditory cortex, Soc Neurosci, 17, 1484
  5. Wilkinson, 1988, Simultaneous analysis of serotonin neuronal activity and release in behaving animals, Soc Neurosci, 14, 662

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Metadata

Authors
Hegerl, U., & Juckel, G.
Affiliations
Freie Universität Berlin (DE)
Corresponding author
Hegerl, Ulrich
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1993-02
Volume
33
Issue
3
Pages
173-187
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/0006-3223(93)90137-3
OpenAlex
W2028129568
Cited by
472
References
148
Citations by year
2026: 3 · 2025: 9 · 2024: 7 · 2023: 8 · 2022: 11 · 2021: 35 · 2020: 17 · 2019: 12 · 2018: 6 · 2017: 14 · 2016: 18 · 2015: 12 · 2014: 18 · 2013: 15 · 2012: 15
FWCI
0.56
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
auditory evoked potentials, N1 and P2 components, stimulus intensity dependence, serotonin, primary auditory cortex, dipole source analysis, non-invasive biomarkers, sensory processing
MeSH terms
Arousal, Attention, Auditory Cortex, Auditory Pathways, Evoked Potentials, Auditory, Humans, Individuality, Loudness Perception, Synaptic Transmission, Serotonin

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