Dopamine D2 receptors in depression measured with single photon emission computed tomography
Abstract
Psychobiological theories of mood disorders have been concerned mainly with noradrenaline and serotonin. There exists, however, a recent upsurge of interest in dopamine. We have used single photon emission computed tomography and 123I-iodobenzamide, a high-affinity ligand for D2 receptors, to study these receptors in depression. Subjects were 21 (unipolar) depressed inpatients and 11 normal controls. The mean basal ganglia/cerebellum uptake ratio was 1.94 (+/- 0.27) in the depressed patients versus 1.74 (+/- 0.17) in the controls. This difference was statistically significant (Mann-Whitney U test, p = 0.025). These data could indicate an increase of D2 receptor density in depression.
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Molecular-imaging studies of DA signaling in MDD indicate increased D2 receptor binding in the basal ganglia, striatum, and putamen, whereas other studies report lower or no difference in striatal D2 transporter binding potential.
“These studies have indicated increased D2 receptor binding in the basal ganglia [257], striatum [258,259], and putamen [260], whereas other studies have reported lower [261] or no difference [259,262,263] in striatal D2 transporter binding potential.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [257]
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References 29 · Cited by 189
- Authors
- D'haenen, H. A., & Bossuyt, A.
- Affiliations
- Université Libre de Bruxelles (BE)
- Vrije Universiteit Brussel (BE)
- Corresponding author
- D'haenen, Hugo A.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 1994-01
- Volume
- 35
- Issue
- 2
- Pages
- 128-132
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2109022596
- Cited by
- 189
- References
- 29
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 5 · 2014: 9 · 2013: 7 · 2012: 7
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- dopamine D2 receptor, depression, receptor density, basal ganglia, cerebellum, radioligand binding, major depressive disorder, mood disorders
- MeSH terms
- Adult, Basal Ganglia, Benzamides, Brain, Cerebellum, Contrast Media, Depressive Disorder, Dopamine, Female, Humans, Male, Middle Aged, Pyrrolidines, Up-Regulation, Tomography, Emission-Computed, Single-Photon, Receptors, Dopamine D2
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