The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Origins of serotonergic projections to the spinal cord in rat: An immunocytochemical-retrograde transport study
Abstract
The origins of the serotonergic projections to the spinal cord in the rat were determined by employing the retrograde cell marker HRP coupled with the unlabeled antibody, peroxidase-antiperoxidase immunocytochemical method of Sternberger. Large numbers of stained neurons (greater than 70%) in the medullary raphe nuclear complex were found to contain both HRP retrogradely transported from the spinal cord and positive 5-HT staining. These serotonergic cell groups, including the nucleus raphe obscurus, raphe pallidus, raphe magnus, and the ventral parts of the reticular formation, project to all spinal cord levels. In addition, some neurons contained HRP granules, but were unstained for 5-HT, suggesting that they may contain other non-serotonergic neurotransmitters. More rostrally in the midbrain reticular formation, many 5-HT neurons were found to have projections exclusively to the cervical spinal cord. These findings indicate that the descending serotonin inputs to the spinal cord originate not only from the serotonergic neurons located in the medullary raphe complex, but also from other new sources located in the central gray and reticular formation of the midbrain.
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“The rest of the DR serotonin neurons were divided into thalamus-projecting and brainstem/cerebellum-projecting groups based on the highest density of axons (Figure 8—figure supplement 3B,C), one of which likely projecting to the spinal cord (brain 36) as previously reported (Bowker et al., 1981; Bowker et al., 1982).”
From Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei (2019) · cites this paper as Bowker et al., 1981
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Cites
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Research works printed but not linked: 2
- Bowker, 1980, Origins and terminations of serotonergic projections to the spinal cord, Neurosci. Abstr., 6, 101
- Steinbusch, 1980, Immunohistochemical characteristics of serotonergic neurons in the central nervous system of the rat, Swedish Neurobiology Club Abstr.
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after cervical spinal cord hemisection in rats 5-Hydroxytryptophan-induced respiratory recovery
Zhou, S.-Y., Goshgarian, H. G., Teng, Y. D., Desilets, F. C., Woodard, E. J., Eichler, M. E., Frontera, W. R., Liao, W.-L., Newton, K. M., Onario, R. C., et al. (2015)
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Interactions between the brain and the immune system in pain and inflammation
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Efeitos termorregulatórios e neuroimunomodulatórios da serotonina
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Yoshiyama, M., & Κakizaki, H. (2023) · Springer eBooks · doi:10.1007/978-981-16-7939-1_4-1
Yoshiyama, M., & Κakizaki, H. (2023) · Springer eBooks · doi:10.1007/978-981-16-7939-1_4-2
Yoshiyama, M., & Κakizaki, H. (2023) · Springer eBooks · doi:10.1007/978-981-99-1659-7_4
Axonal Transport Tracing Combined with Neurotransmitter and Peptide Immunocytochemistry
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Central Control of Nociception
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Mothe, A. J., HASSOUNA, M. M., Ahuja, C. S., Jacobson, P. B., Huang, L., Fehlings, M. G., Monnier, P. P., & Tator, C. H. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119769
Mikhailova, M., V’yunova, T. V., Sysoev, Y. I., Butylin, A., Sungurova, A., & Евгеньевич, М. П. (2026) · Reviews in the Neurosciences · doi:10.1515/revneuro-2026-0121
Metadata
- Authors
- Bowker, R. M., Westlund, K. N., & Coulter, J. D.
- Affiliations
- The University of Texas Medical Branch at Galveston (US)
- ORCID
- Westlund, K.N.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1981-12
- Volume
- 226
- Issue
- 1-2
- Pages
- 187-199
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1976119196
- Cited by
- 317
- References
- 27
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 4 · 2022: 6 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 6 · 2014: 5 · 2013: 6 · 2012: 5
- FWCI
- 6.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- serotonergic projections, spinal cord, nucleus raphe obscurus, nucleus raphe pallidus, nucleus raphe magnus, reticular formation, midbrain reticular formation, periaqueductal gray, serotonergic neurons, retrograde tracing, HRP
- MeSH terms
- Animals, Brain Stem, Horseradish Peroxidase, Immunoenzyme Techniques, Medulla Oblongata, Mesencephalon, Neural Pathways, Neurons, Pons, Raphe Nuclei, Reticular Formation, Serotonin, Spinal Cord, Rats
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