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The laminar sensitivity of cat striate cortex to penicillin induced epileptogenesis
Abstract
By utilizing the microinjection of low nanoliter volumes of convulsant drug and recording from the injection site, we have been able to electrophysiologically identify a layer of cat striate cortex that is most sensitive to the epileptogenic effects of penicillin. This band encompasses cortical depths of approximately 1000-1250 micrometers when the smallest volumes of penicillin are injected. Comparable penicillin injections made either superficial to or deeper than this were not as effective in producing epileptiform alterations in normal activity. Histochemical marks made at the site of these injections have identified cortical cytoarchitectonic layer IV as the site of maximal neocortical penicillin sensitivity. The vulnerability of layer IV to penicillin epileptogenesis may be related to certain distinctive anatomic features of this layer.
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Epileptiform activity during initiation of epileptic discharges in the neocortex suggests enhanced postsynaptic activity.
“Epileptiform activity during initiation of epileptic discharges in the neocortex [52] suggests enhanced postsynaptic activity [53].”
From Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin D1 (2015) · cites this paper as [52]
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References 18 · Cited by 45
Research works printed but not linked: 9
- Chatt, 1979, Intracortical evoked responses recorded from peri-focus electrade sites following penicillin induced epileptic discharges in cat visual cortex, Neurosci. Abstr., 3, 190
- Chatt, 1980, Autoradiographic identification of the cortical laminae involved in the generation of a discrete intracortical epileptic focus, Neurosci. Abstr., 6, 402
- Chatt, 1981, Evidence for the neocortical microcircuitry involved in epileptogenesis, Neurosci. Abstr., 7, 812
- Connors, 1981, Electrophysiological properties of neocortical neurons maintained in vivo, Neurosci. Abstr., 7, 593
- Ebersole, 1979, Alteration of intracortical evoked potentials during focal penicillin epileptogenesis in cat visual cortex, Neurosci. Abstr., 3, 191
- Ebersole, 1980, The laminar susceptibility of cat visual cortex to penicillin-induced epileptogenesis, Neurology, 30, 355
- Ebersole, 1981, Cortical laminar epileptic foci from penicillin microinjection: differential sensitivity, interdependence, and polarity changes with development, Neurology, 31, 52
- Traub, 1981, Simulations of the CA3 hippocampal region: single cells, electrotonic interactions, synchronization, and seizures, Neurosci. Abstr., 7, 590
- Wong, 1978, Penicillin blocks inhibitory control of dendrite burst generation in hippocampal neurons, Neurosci. Abstr., 4, 239
Metadata
- Authors
- Chatt, A. B., & Ebersole, J. S.
- Affiliations
- United States Department of Veterans Affairs (US)
- ORCID
- Ebersole, John S.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1982-06
- Volume
- 241
- Issue
- 2
- Pages
- 382-387
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2049778040
- Cited by
- 45
- References
- 18
- Citations by year
- 2018: 1 · 2015: 1
- FWCI
- 3.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- penicillin, epileptogenesis, primary visual cortex, cat visual cortex, layer 4, cytoarchitecture, convulsant drugs, microinjection, epileptiform activity
- MeSH terms
- Action Potentials, Animals, Cats, Evoked Potentials, Kinetics, Penicillin G, Seizures, Visual Cortex
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