The DOI matches its Crossref record; 15 of the 16 references it cites were found in a registry or an index.
Analgesia elicited by prefrontal stimulation
Abstract
Bipolar stimulating electrodes were placed into the medial prefrontal cortex (PFC) or control sites (occipital or cerebellar cortices) in adult male rats. Subsequently, it was determined that PFC stimulation resulted in a significant elevation of nociceptive response latencies, as tested using hot plate and tail flick techniques. Stimulation in control sites did not produce an increase in these response latencies. Rats receiving PFC stimulation were able to respond normally to various innocuous stimuli. Furthermore, seizures were not observed in these rats. These facts indicated that PFC stimulation did not disorient the animals nor inhibit their voluntary motor activity. The results of this study seem to indicate that the PFC is a site from which stimulus-produced analgesia may be elicited.
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“The insula, a region of the cerebral cortex, is known to be involved in critical aspects underlying SUDs, such as interoception, decision making, anxiety, pain perception, cognition, mood, threat recognition, and conscious urges.”
From The Insula: A Brain Stimulation Target for the Treatment of Addiction (2019) · cites this paper as Hardy, 1985
Citations
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Butler, R. K., & Finn, D. P. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.003 · Cited by 768
Reward Circuitry Activation by Noxious Thermal Stimuli
Becerra, L. R., Breiter, H. C., Wise, R. A., González, R., & Borsook, D. (2001) · Neuron · doi:10.1016/s0896-6273(01)00533-5 · Cited by 501
Pain-related cerebral activation is altered by a distracting cognitive task
Petrović, P., Petersson, K. M., Ghatan, P. H., Stone‐Elander, S., & Ingvar, M. (2000) · Pain · doi:10.1016/s0304-3959(99)00232-8 · Cited by 419
Cortical responses to pain in healthy individuals depends on pain catastrophizing
Seminowicz, D. A., & Davis, K. D. (2006) · Pain · doi:10.1016/j.pain.2005.11.008 · Cited by 407
Metadata
- Authors
- Patrick Hardy, S. G.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1985-07
- Volume
- 339
- Issue
- 2
- Pages
- 281-284
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1978774896
- Cited by
- 133
- References
- 16
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 10 · 2018: 4 · 2017: 1 · 2016: 5 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2s07rr005386-30)
- National Center for Research Resources (5 S07 RR05386)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Keywords
- medial prefrontal cortex, electrical stimulation, nociception, hot plate test, tail flick, bipolar electrodes, seizures, rats
- MeSH terms
- Analgesia, Animals, Brain Mapping, Electric Stimulation, Frontal Lobe, Male, Neural Pathways, Pain, Periaqueductal Gray, Rats, Inbred Strains, Reaction Time, Superior Colliculi, Rats
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