Stimulation of spinal serotonergic receptors facilitates seminal emission and suppresses penile erectile reflexes
Abstract
Penile erection and ejaculation are produced by spinal reflexes subject to tonic control from the brain. This study examines the possible involvement of serotonergic transmission in the supraspinal modulation of such reflexes. The effects of two drugs which facilitate serotonergic transmission by different mechanisms, namely the direct receptor agonist, 5-methoxy-N,N'-dimethyltryptamine (5-MeODMT), and the reuptake inhibitor, zimelidine, were compared in intact and spinal rats. Results show that serotonergic stimulation in intact rats by either drug produces a dose-related increase in the incidence of seminal emission as well as a definite decrease of the display of erectile responses. In the spinal animals 5-MeODMT treatment reproduced both effects. By contrast, zimelidine, which needs functional nerve endings to exert its agonistic action, was ineffective in the spinal rats. This is interpreted to exclude a peripheral mechanism for the effects of the serotonin agonists on penile reflexes of intact animals and makes a strong case for a spinal site of action. We postulate the existence of serotonergic receptors located in the lower segments of the spinal cord which, when stimulated, trigger seminal emission and suppress erection.
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The behavior of the exposed offspring is reminiscent of male rats administered serotonin receptor agonists or agents that block nitric oxide synthesis.
“The behavior of the exposed offspring is also reminiscent of male rats that have been administered serotonin receptor agonists (Mas et al. 1985) or agents that block the synthesis of nitric oxide (Hull et al. 1994).”
From Perinatal Exposure to Low Levels of the Environmental Antiandrogen Vinclozolin Alters Sex-Differentiated Social Play and Sexual Behaviors in the Rat (2005) · cites this paper as Mas et al. 1985
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- Authors
- Mas, M., Zahradnik, M. A., Martino, V., & Davidson, J. M.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Davidson, J.M.
- ORCID
- Mas, M.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1985-09
- Volume
- 342
- Issue
- 1
- Pages
- 128-134
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1975569659
- Cited by
- 86
- References
- 0
- Citations by year
- 2021: 1
- FWCI
- 7.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (NIMH 21178)
- Fogarty International Center (FO 5 TW03196)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Urology › Urinary Bladder and Prostate Research
- Keywords
- serotonergic receptors, spinal cord, seminal emission, penile erection, ejaculation, 5-MeO-DMT, zimelidine, serotonin reuptake inhibition, serotonin receptor agonists, supraspinal modulation, spinal reflexes
- MeSH terms
- Animals, Ejaculation, Male, Methoxydimethyltryptamines, Penile Erection, Receptors, Serotonin, Reflex, Spinal Cord, Zimeldine, Rats
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