CoChat
Sign Up
Cited by 26Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

The DOI matches its Crossref record.

125I-LSD autoradiography confirms the preferential localization of caudate-putamen S2 receptors to the caudal (peripallidal) region

Altar, C. Anthony, Boyar, William C., Marien, Marc R.·1986·Brain Research
DOI 10.1016/0006-8993(86)91465-4
Open this paper in CoChat — free account

Abstract

The in vitro binding of 125I-lysergic acid diethylamide (LSD) to horizontal sections of rat brain was quantified with computer-assisted autoradiography. Specific binding of 125I-LSD to D2 and S2 sites, defined with 5 microM (+)-butaclamol, was 65-94% of the total binding. Identification of S2 sites with 50 nM ketanserin showed that over 90% of the butaclamol-displaced 125I-LSD binding in the frontal, cingulate and parietal neocortex was to S2 sites (22-55 fmol/mg protein). 125I-LSD also labeled a dense population of S2 sites (16 fmol/mg protein) in the caudal caudate-putamen at the level of the globus pallidus which exceeded by 5-fold the concentration of S2 sites (3 fmol/mg protein) in more rostral portions of the caudate-putamen. The peripallidal distribution of S2 sites was identical to that observed previously with the less selective S2 label, [3H]spiperone. The dense concentration of S2 sites in the caudal caudate-putamen and their overlap with D2 binding sites indicates that the peripallidal neostriatum may play an important role in interactions between dopamine and serotonin.

Overview

Integrity signals

Registry

Crossref · 10.1016/0006-8993(86)91465-4

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Other binding studies with [125I]-LSD revealed a significant ketanserin displaceable component in rat striatum sections, ranging from 30% in rostral parts to 74% in caudal regions.

    “However, other binding studies with [125I]-LSD (25) revealed a significant ketanserin (7) displaceable component in rat striatum sections, ranging from 30% in rostral parts to 74% in the caudal regions [74].”

    From Molecular and Functional Imaging Studies of Psychedelic Drug Action in Animals and Humans. (2021) · cites this paper as [74]

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 41

  1. Alexander, 1981, Quantitative measurement of local cerebral metabolic rate for glucose utilizing tritiated 2-deoxyglucose, Brain Research, 223, 59, 10.1016/0006-8993(81)90806-4 · DOI
  2. Altar, 1984, An easily constructed and inexpensive three layer cassette for tritium-sensitive film autoradiography, J. Pharmacol. Meth., 12, 225, 10.1016/0160-5402(84)90064-0 · DOI
  3. Altar, 1985, Computer imaging and analysis of dopamine (D2) and serotonin (S2) binding sites in rat basal ganglia or neocortex labeled by [3H] spiroperidol, J. Pharmacol. Exp. Ther., 233, 527
  4. Altar, 1985, Brain dopamine and serotonin receptor sites revealed by digital subtraction autoradiography, Science, 228, 597, 10.1126/science.2580352 · DOI
  5. Altar, 1984, Computer-assisted video analysis of [3H]spiroperidol binding autoradiographs, J. Neurosci. Meth., 10, 173, 10.1016/0165-0270(84)90054-2 · DOI
  6. Altar, C.A., Wasley, A.M. and Martin, L.L., Autoradiographic localization and pharmacology of unique [3H]tryptamine binding sites in rat brain,Neuroscience, in press. · DOI
  7. Altar, 1984, Clozapine, an atypical antipsychotic, attenuates haloperidol catalepsy, Pharmacologist, 26, 179
  8. Biegon, 1984, Quantitative autoradiographic localization of serotonin receptors in the human brain postmortem, Soc. Neurosci. Abstr., 10, 380
  9. Biegon, 1982, Quantitative autoradiography of serotonin receptors in rat brain, Brain Research, 242, 297, 10.1016/0006-8993(82)90301-8 · DOI
  10. Bockaert, 1977, Topographical distribution and characteristics of dopamine and β-adrenergic sensitive adenylate cyclases in the rat frontal cerebral cortex, striatum, and substantia nigra, Adv. Biochem. Psychopharmacol., 16, 29
  11. DiPaolo, 1982, Distribution of dopamine in 35 subregions of the rat caudate-putamen: a high performance liquid chromatography with electrochemical detection analysis, J. Sci. Neurol., 9, 421, 10.1017/S0317167100044334 · DOI
  12. Engel, 1984, 2-[125Iodo]LSD, a new ligand for the characterization and localization of 5HT2 receptors, Naunyn-Schmiedeberg's Arch. Pharmacol., 325, 328, 10.1007/BF00504377 · DOI
  13. Ennis, 1981, Characterization of imhibitory 5-hydroxytryptamine receptors that modulate dopamine release in the striatum, J. Neurochem., 36, 1515, 10.1111/j.1471-4159.1981.tb00594.x · DOI
  14. Fink, 1984, Clozapine—a serotonin antagonist?, Pharmacol. Biochem. Behav., 20, 513, 10.1016/0091-3057(84)90297-1 · DOI
  15. Groppetti, 1978, 3-Methoxytyramine and different neuroleptics: dissociation from HVA and DOPAC, Life Sci., 23, 1763, 10.1016/0024-3205(78)90105-4 · DOI
  16. Hartig, 1985, [125I]LSD binding to serotonin and dopamine receptors in bovine caudate membranes, Neurochem. Int., 7, 699, 10.1016/0197-0186(85)90068-3 · DOI
  17. Hartig, 1983, [125I]LSD: a selective, high sensitivity ligand for serotonin 5HT2 receptors, Soc. Neurosci. Abstr., 9, 334
  18. Herkenham, 1982, Light microscopic localization of brain opiate receptors: a general autoradiographic method which preserves tissue quality, J. Neurosci., 2, 1129, 10.1523/JNEUROSCI.02-08-01129.1982 · DOI
  19. Herkenham, 1983, Quantification of receptor densities by autoradiography: tissue defatting minimizes differential absorbance of tritium by gray and white matter, Soc. Neurosci. Abstr., 9, 329
  20. Howlett, 1980, Quantitative assessment of heterogeneous3H-spiperone binding to rat neostriatum and frontal cortex, Life Sci., 26, 511, 10.1016/0024-3205(80)90313-6 · DOI
  21. Kadan, 1984, Characterization of [125I]lysergic acid diethylamide binding to serotonin receptors in rat frontal cortex, J. Neurochem., 43, 601, 10.1111/j.1471-4159.1984.tb12777.x · DOI
  22. Kuczenski, 1979, Effects of para-chlorophenylalanine on amphetamine and haloperidol-induced changes in striatal dopamine turnover, Brain Research, 164, 217, 10.1016/0006-8993(79)90017-9 · DOI
  23. Leysen, 1981, Receptor binding profile of R 41 468, a novel antagonist at 5HT2 receptors, Life Sci., 28, 1015, 10.1016/0024-3205(81)90747-5 · DOI
  24. Lowry, 1951, Protein measurement with the folin phenol reagent, J. Biol. Chem., 193, 265, 10.1016/S0021-9258(19)52451-6 · DOI
  25. Meibach, 1980, Characterization and radioautography of [3H]LSD binding by rat brain slices in vitro: the effect of 5-hydroxytryptamine, Eur. J. Pharmacol., 67, 371, 10.1016/0014-2999(80)90178-8 · DOI
  26. Mogilnicka, 1977, The influence of antiserotonergic agents on the action of dopaminergic drugs, Pol. J. Pharmacol., 29, 31
  27. Morgan, 1984, Contamination of serotonin2 binding sites by an alpha1 adrenergic component in assays with [3H]spiperone, Life Sci., 34, 2507, 10.1016/0024-3205(84)90288-1 · DOI
  28. Nakada, 1984, Localization and characterization by quantitative autoradiography of [125I]LSD binding sites in rat brain, Neurosci. Lett., 49, 13, 10.1016/0304-3940(84)90128-9 · DOI · Paper page
  29. Neve, 1984, Quantitative analysis of [3H]spiroperidol binding to rat forebrain sections: plasticity of neostriatal dopamine receptors after nigrostriatal injury, Brain Research, 302, 9, 10.1016/0006-8993(84)91280-0 · DOI
  30. Nicolau, 1979, Interactions between serotonergic and dopaminergic systems in rat brain demonstrated by small unilateral lesions of the raphénuclei, Eur. J. Pharmacol., 57, 295, 10.1016/0014-2999(79)90492-8 · DOI
  31. Palacios, 1981, [3H]Spiperone binding sites in brain: autoradiography localization of multiple receptors, Brain Research, 213, 277, 10.1016/0006-8993(81)90234-1 · DOI
  32. Pedigo, 1978, [3H]Spiroperidol binding to two receptor sites in both the corpus striatum and frontal cortex of rat brain, Eur. J. Pharmacol., 50, 451, 10.1016/0014-2999(78)90154-1 · DOI
  33. Peroutka, 1979, Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol, Mol. Pharmacol., 16, 687
  34. Quik, 1979, Regional study of [3H]spiperone binding and the dopamine-sensitive adenylate cyclase in rat brain, Eur. J. Pharmacol., 56, 323, 10.1016/0014-2999(79)90262-0 · DOI
  35. Steinbusch, 1981, Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals, Neuroscience, 6, 557, 10.1016/0306-4522(81)90146-9 · DOI · Paper page
  36. Sulpizio, 1978, Antagonism of fenfluramine-induced hyperthermia: a measure of central serotonin inhibition, Life Sci., 22, 1439, 10.1016/0024-3205(78)90638-0 · DOI
  37. Tassin, 1976, Topographical distribution of dopaminergic innervation and of dopaminergic receptors in the rat striatum. I. Microestimation of [3H]dopamine uptake and dopamine content in microdiscs, Brain Research, 107, 291, 10.1016/0006-8993(76)90227-4 · DOI
  38. Ternaux, 1977, The topographical distribution of serotonergic terminals in the neostriatum of the rat and caudate nucleus of the cat, Brain Research, 121, 311, 10.1016/0006-8993(77)90154-8 · DOI
  39. Unnerstall, 1982, Quantitative receptor autoradiography using [3H]ultrofilm: application to multiple benzodiazepine receptors, J. Neurosci. Meth., 6, 59, 10.1016/0165-0270(82)90016-4 · DOI
  40. Waldmeier, 1979, Serotonin-dopamine interactions in the nigrostriatal system, Eur. J. Pharmacol., 55, 363, 10.1016/0014-2999(79)90110-9 · DOI
  41. Young, 1980, Serotonin receptor localization in rat brain by light microscopic autoradiography, Eur. J. Pharmacol., 62, 237, 10.1016/0014-2999(80)90284-8 · DOI

Cited by

Sorted by citations

Metadata

Authors
Altar, C. A., Boyar, W. C., & Marien, M. R.
Corresponding author
Altar, C. Anthony
Venue
Brain Research
Publisher
Elsevier BV
Published
1986-04
Volume
372
Issue
1
Pages
130-136
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(86)91465-4
OpenAlex
W2019210181
Cited by
26
References
0
Citations by year
2021: 1
FWCI
1.09
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
serotonin receptors, dopamine D2 receptor, caudate-putamen, globus pallidus, butaclamol, ketanserin, spiperone, serotonin-dopamine interaction, rat brain
MeSH terms
Animals, Autoradiography, Butaclamol, Caudate Nucleus, Frontal Lobe, Iodine Radioisotopes, Ketanserin, Lysergic Acid Diethylamide, Male, Piperidines, Putamen, Rats, Inbred Strains, Receptors, Serotonin, Serotonin, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review