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Method of administration determines the effect of naloxone on pain
Abstract
The opiate antagonist, naloxone, produces dose-dependent biphasic changes in clinical pain. The mechanism of the analgesia produced by low dose naloxone is unknown. To study the analgesic effect of naloxone, we have used a programmable infusion pump, which eliminates placebo-induced endorphin-mediated analgesia, to administer different doses of naloxone. We report that use of machine infusion of naloxone exclusively produces analgesia. The implications of this finding to the mechanism of naloxone-induced analgesia are discussed.
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The naloxone dose (0.15 mg/kg bolus + 0.1 mg/kg/h infusion) comprehensively antagonizes endogenous opioids.
“This large dose comprehensively antagonizes endogenous opioids (Levine and Gordon, 1986) and is larger than dosages previously used to successfully reverse analgesia produced by placebo (Levine et al., 1978;Grevert et al., 1983;Amanzio and Benedetti, 1999;Benedetti et al., 1999), electrical stimulation of periventricular gray matter (Adams, 1976;Hosobuchi et al., 1977), transcranial magnetic stim”
From Mindfulness-meditation-based pain relief is not mediated by endogenous opioids (2016) · cites this paper as Levine and Gordon, 1986
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References 12 · Cited by 54
Research works printed but not linked: 10
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- Levine, 1979, Naloxone dose-dependently produces analgesia and hyperalgesia in postoperative pain, Nature (London), 278, 740, 10.1038/278740a0 · DOI
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Metadata
- Authors
- Levine, J. D., & Gordon, N. C.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Levine, Jon D.
- ORCID
- Levine, Jon D.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1986-02
- Volume
- 365
- Issue
- 2
- Pages
- 377-378
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1973660716
- Cited by
- 54
- References
- 12
- Citations by year
- 2021: 1 · 2020: 2 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2013: 1 · 2012: 4
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01am032634-03)
- National Institute of Neurological Disorders and Stroke (NS21642)
- National Institute of Dental and Craniofacial Research (DE05369)
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- naloxone, analgesia, opioid antagonists, administration methods, intravenous infusion, placebo effect, pain
- MeSH terms
- Analgesics, Double-Blind Method, Humans, Injections, Intravenous, Naloxone, Postoperative Pain, Tooth Extraction, Tooth, Impacted
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