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Effects of xylazine on cerebrospinal fluid catecholamines in the rhesus monkey
Abstract
The i.v. administration of xylazine, a potent, selective alpha 2-adrenergic receptor agonist, resulted in a 76% decrease in cerebrospinal fluid (CSF) norepinephrine in chair-adapted rhesus monkeys. A significant decrease was observed within 1.5 h of administration and continued through the 3 h course of sampling. Dopamine was maximally decreased by 24% at 1.5 h. Epinephrine was not significantly decreased following xylazine administration. These data suggest that norepinephrine release into monkey CSF, as an index of central or peripheral norepinephrine turnover, is more sensitive to alpha 2-adrenergic agonists than in CSF dopamine or epinephrine.
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Anesthesia potently suppresses norepinephrine release and vasomotion.
“Anesthesia potently suppresses NE release and vasomotion71–73”
From Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep (2025) · cites this paper as [71]
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Research works printed but not linked: 15
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Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep
Hauglund, N. L., Andersen, M., Tokarska, K., Radovanovic, T., Kjaerby, C., Sørensen, F. L., Bojarowska, Z., Untiet, V., Ballestero, S. B., Kolmos, M. G., et al. (2025) · Cell · doi:10.1016/j.cell.2024.11.027 · Cited by 349
Leckman, J. F., Goodman, W. K., Anderson, G. M., Riddle, M. A., Chappell, P. B., McSwiggan-Hardin, M. T., McDougle, C. J., Scahill, L. D., Ort, S. I., Pauls, D. L., et al. (1995) · Neuropsychopharmacology · doi:10.1038/sj.npp.1380241 · Cited by 169
Metadata
- Authors
- Mefford, I. N., & Garrick, N. A.
- Affiliations
- National Institute of Mental Health (US)
- Corresponding author
- Mefford, Ivan N.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1989-07
- Volume
- 492
- Issue
- 1-2
- Pages
- 377-380
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2017747037
- Cited by
- 7
- References
- 0
- Citations by year
- 2025: 2 · 2020: 1
- FWCI
- 0.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- xylazine, cerebrospinal fluid, catecholamines, norepinephrine, dopamine, epinephrine, alpha-2 adrenergic agonists, rhesus monkeys, norepinephrine turnover, central nervous system
- MeSH terms
- Adrenergic alpha-Agonists, Animals, Catecholamines, Female, Hypnotics and Sedatives, Macaca mulatta, Male, Thiazines, Time Factors, Xylazine
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