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Cited by 163

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Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats: Behavioral and biochemical evidence

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Cadet, Jean Lud, Katz, Mindy, Jackson-Lewis, Vernice, Fahn, Stanley·1989·Brain Research
DOI 10.1016/0006-8993(89)91530-8
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Abstract

Unilateral 6-hydroxydopamine (6-OHDA) injections into the striatum lead to the development of apomorphine-induced rotation in rats. The circling behavior was associated with significant decreases in dopamine, dihydroxyphenylacetic acid and homovanillic acid in the ipsilateral striatum. Pretreatments with either D-alpha-tocopherol or all-racemic-alpha-tocopherol caused significant attenuation of both the behavioral and biochemical abnormalities. These results are discussed in terms of their support for the free radical hypothesis of Parkinson's disease and for the role of antioxidants in the treatment of this neurodegenerative disorder.

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Metadata

Authors
Cadet, J. L., Katz, M., Jackson-Lewis, V., & Fahn, S.
Venue
Brain Research
Publisher
Elsevier BV
Published
1989-01
Volume
476
Issue
1
Pages
10-15
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(89)91530-8
OpenAlex
W2018290969
Cited by
163
References
0
FWCI
6.77
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats: Behavioral and biochemical evidence. https://app.cochat.ai/papers/10.1016/0006-8993(89)91530-8
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Cadet, J. L., Katz, M., Jackson-Lewis, V., & Fahn, S. (1989). Vitamin E attenuates the toxic effects of intrastriatal injection of 6-hydroxydopamine (6-OHDA) in rats: Behavioral and biochemical evidence. Brain Research. https://doi.org/10.1016/0006-8993(89)91530-8

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