The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
MK-801 reduced cerebral ischemic injury by inducing hypothermia
Abstract
The non-competitive N-methyl-D-aspartate (NMDA) antagonist, MK-801, has been reported to prevent or attenuate ischemic brain damage in various animal models. In halothane-anesthetized gerbils it was found that an optimal dose of MK-801 (3.0 mg/kg) for providing cerebral protection also produced hypothermia (31.1 +/- 0.62 degrees C) relative to control animals (34.2 +/- 0.77 degrees C, P less than 0.01). This degree of hypothermia alone was sufficient to provide complete histological and functional protection (spatial memory) against 5 min of carotid artery occlusion. In gerbils made ischemic, but maintained at normal body temperature, a dose of 3.0 mg/kg of MK-801 provided no protection against hippocampal cell loss or spatial memory impairment. These data suggest that the protective actions of MK-801 may be due entirely to drug-induced hypothermia.
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In vivo rodent global ischemia data and human clinical stroke trials have been unable to indicate a clear causal role of NMDA receptors under the conditions in which receptor antagonists were applied.
“However, in vivo rodent global ischemia data (Corbett et al., 1990;Diemer et al., 1992;Olsson et al., 2003), as well as human clinical stroke trials (Lee et al., 1999;Hoyte et al., 2004;Simon, 2006) have been unable to indicate a clear causal role of these receptors under the conditions in which receptor antagonists were applied.”
From Two-Photon Imaging of Stroke Onset In Vivo Reveals That NMDA-Receptor Independent Ischemic Depolarization Is the Major Cause of Rapid Reversible Damage to Dendrites and Spines (2008) · cites this paper as Corbett et al., 1990
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Cites
Zola-Morgan, S., Squire, L., & Amaral, D. (1986) · The Journal of Neuroscience · doi:10.1523/jneurosci.06-10-02950.1986 · Cited by 1,997
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Research works printed but not linked: 16
- Boast, 1988, The N-methyl-d-aspartate antagonists CGS 19755 and CPP reduce is chemic brain damage in gerbils, Brain Research, 422, 345, 10.1016/0006-8993(88)91522-3 · DOI
- Buchan, 1989, Are the neuroprotective effects of MK-801 mediated by hypothermia?, Stroke, 28, 148
- Busto, 1987, Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury, J. Cereb. Blood Flow Metab., 7, 729, 10.1038/jcbfm.1987.127 · DOI
- Connolly, 1962, The protective effect of hypothermia in cerebral ischemia: experimental and clinical applications by selective brain cooling in the human, Surgery, 52, 15
- Foster, 1987, The novel anticonvulsant MK-801 binds to the activated state of the N-methyl-d-aspartate receptor in rat brain, Br. J. Pharmacol., 91, 403, 10.1111/j.1476-5381.1987.tb10295.x · DOI
- Gerhardt, 1988, Motor activity changes following cerebral ischemia in gerbils are correlated with the degree of neuronal degeneration in hippocampus, Behav. Neurosci., 102, 301, 10.1037/0735-7044.102.2.301 · DOI
- Gill, 1987, Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil, J. Neurosci., 7, 3343, 10.1523/JNEUROSCI.07-10-03343.1987 · DOI
- Gill, 1988, MK-801 is neuroprotective in gerbils when administered during the post-ischaemic period, Neuroscience, 25, 847, 10.1016/0306-4522(88)90040-1 · DOI
- Hattori, 1989, Posthypoxic treatment with MK-801 reduces hypoxic-ischemic damage in the neonatal rat, Neurology, 39, 713, 10.1212/WNL.39.5.713 · DOI
- Kimble, 1975, Choice behavior in rats with hippocampal lesions, Vol. 2, 309
- Meldrum, 1985, Excitatory amino acids and anoxic/ischaemic brain damage, Trends Neurosci., 47, 10.1016/0166-2236(85)90024-4 · DOI
- Olney, 1989, MK-801 prevents hypobaric-ischemic neuronal degeneration in infant rat brain, J. Neurosci., 9, 1701, 10.1523/JNEUROSCI.09-05-01701.1989 · DOI
- Park, 1988, The glutamate antagonist MK-801 reduces focal ischemic brain damage in the rat, Ann. Neurol., 24, 543, 10.1002/ana.410240411 · DOI
- Rothman, 1986, Glutamate and the pathophysiology of hypoxic-ischemic brain damage, Ann. Neurol., 19, 105, 10.1002/ana.410190202 · DOI
- Siesjö, 1989, Calcium fluxes, calcium antagonists and calcium-related pathology in brain ischemia, hypoglycemia, and spreading depression: a unifying hypothesis, J. Cereb. Blood Flow Metab., 9, 127, 10.1038/jcbfm.1989.20 · DOI · Paper page
- Simon, 1984, Blockade of N-methyl-d-aspartate receptors may protect against ischemic damage in the brain, Science, 226, 850, 10.1126/science.6093256 · DOI
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Murphy, T. H., Li, P., Betts, K., & Liu, R. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5128-07.2008 · Cited by 261
“Although MK-801 has been routinely administered by intraperitoneal injection (Corbett et al., 1990), we noticed that some animals given systemic MK-801 may have developed respiratory problems.”
BackgroundInfluential
Metadata
- Authors
- Corbett, D., Evans, S., Thomas, C., Wang, D., & Jonas, R. A.
- Affiliations
- Memorial University of Newfoundland (CA)
- Harvard University (US)
- Corresponding author
- Corbett, Dale
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1990-04
- Volume
- 514
- Issue
- 2
- Pages
- 300-304
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W1978428462
- Cited by
- 205
- References
- 1
- Citations by year
- 2026: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2018: 1 · 2016: 2 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 18.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- MK-801, cerebral ischemia, hypothermia, NMDA receptor antagonists, neuroprotection, carotid artery occlusion, hippocampal neuronal loss, spatial memory impairment, gerbils, body temperature
- MeSH terms
- Animals, Body Temperature Regulation, Ischemic Attack, Transient, Dibenzocycloheptenes, Female, Gerbillinae, Hypothermia, Receptors, N-Methyl-D-Aspartate, Dizocilpine Maleate, Receptors, Neurotransmitter
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