Degeneration of the nigral dopamine neurons after 6-hydroxydopamine injection into the rat striatum
Abstract
6-Hydroxydopamine (6-OHDA) was injected into the rat striatum unilaterally. After 2-4 weeks, a marked decrease in the number of tyrosine hydroxylase-immunoreactive neuronal perikarya and dendrites was observed in the substantia nigra (SN) ipsilateral to the injection. Nissl staining showed a severe cell loss in the same region and electron microscopy revealed neuronal perikarya under degenerating process in the SN. The results showed a retrograde cytotoxic effect of 6-OHDA from the striatal terminals to their dopaminergic neuronal perikarya in the SN, and suggest the possibility that the striatum may be a primary locus in the degeneration process in Parkinson's disease.
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6-OHDA is a neurotoxin that induces loss of SNc DA neurons when injected into the DLS by causing dying back of SNc DA neuron axonal terminals.
“6-OHDA is a neurotoxin that induces loss of SNc DA neurons when injected into the DLS by causing a dying back of SNc DA neuron axonal terminals in the DLS (Fig. 6B) (Ichitani et al. 1991).”
From Mitochondrial DNA Damage in Substantia Nigra Pars Compacta Astrocytes Exacerbates Dopaminergic Neuron Loss in a 6-Hydroxydopamine Mouse Model of Parkinsonism (2026) · cites this paper as Ichitani et al. 1991
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Ayala, D. A., Hall, G. M., Das, D., Tijerina, E., Villagran, L. L., Khan, Z., Paliwal, D., Anand, A., Rimer, M., & Srinivasan, R. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01713-x · Cited by 1 · see citing works
- Authors
- Ichitani, Y., Okamura, H., Matsumoto, Y., Nagatsu, I., & Ibata, Y.
- Affiliations
- Kyoto Prefectural University of Medicine (JP)
- Fujita Health University (JP)
- Corresponding author
- Ibata, Yasuhiko
- ORCID
- Okamura, Hitoshi
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1991-05
- Volume
- 549
- Issue
- 2
- Pages
- 350-353
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2035388674
- Cited by
- 96
- References
- 0
- Citations by year
- 2026: 1 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 1 · 2015: 2 · 2014: 1 · 2012: 4
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- 6-hydroxydopamine, substantia nigra, dopaminergic neuron loss, striatum, retrograde degeneration, tyrosine hydroxylase, Parkinson's disease, neuronal loss
- MeSH terms
- Animals, Corpus Striatum, Hydroxydopamines, Immunohistochemistry, Injections, Male, Microscopy, Electron, Nerve Degeneration, Neurons, Rats, Inbred Strains, Substantia Nigra, Tyrosine 3-Monooxygenase, Oxidopamine, Rats
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