5a-Pregnane-3a,21-diol-20-one (THDOC) attenuates mild stress-induced increases in plasma corticosterone via a non-glucocorticoid mechanism: comparison with alprazolam
Abstract
5 alpha-Pregnane-3 alpha,21-diol-20-one (THDOC; 5 mg/kg) and the triazolobenzodiazepine alprazolam (1 mg/kg) attenuated mild stress-induced increases in plasma corticosterone concentrations via GABAergic mechanisms. Unlike alprazolam, THDOC failed to decrease corticotropin-releasing factor (CRF) concentrations in the locus ceruleus. While THDOC may plausibly act via endogenous GABAergic mechanisms to reduce stress-induced endocrine and behavioral responses that are likely mediated in part by CRF neurons, these preliminary findings suggest that, at the dose and time point studied, THDOC does not identically mimic the actions of alprazolam, another drug which potentiates GABAergic activity.
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Tetrahydrodeoxycorticosterone (TH-DOC) attenuates HPA axis function.
“another potent GABAA receptor modulator and deoxycorticosterone-derived steroid, tetrahydrodeoxycorticosterone (TH-DOC), also attenuates the HPA axis function (77, 82, 83).”
From Higher Circulating Cortisol in the Follicular vs. Luteal Phase of the Menstrual Cycle: A Meta-Analysis (2020) · cites this paper as [82]
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References 16 · Cited by 77
- Authors
- Owens, M. J., Ritchie, J. C., & Nemeroff, C. B.
- Affiliations
- Duke Medical Center (US)
- Duke University (US)
- Corresponding author
- Nemeroff, Charles B.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1992-02
- Volume
- 573
- Issue
- 2
- Pages
- 353-355
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2084775431
- Cited by
- 77
- References
- 16
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 6 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 8 · 2018: 2 · 2015: 2 · 2014: 8 · 2013: 1
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH042088, MH42088)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- alprazolam, corticosterone, stress response, GABAergic mechanisms, corticotropin-releasing factor, locus coeruleus, triazolobenzodiazepines
- MeSH terms
- Alprazolam, Animals, Corticosterone, Corticotropin-Releasing Hormone, Desoxycorticosterone, Dexamethasone, Locus Coeruleus, Male, Median Eminence, Rats, Inbred Strains, Reference Values, Stress, Physiological, Rats
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