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Cited by 75Neurogenesis and neuroplasticity mechanismsNerve injury and regenerationTGF-β signaling in diseases

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Transforming growth factor-β1 and -β2 promote neurite sprouting and elongation of cultured rat hippocampal neurons

Ishihara, Akane, Saito, Hiroshi, Abe, Kazuho·1994·Brain Research
DOI 10.1016/0006-8993(94)91759-0
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Abstract

Transforming growth factor-beta (TGF-beta) is known as a potent regulator of cell proliferation and differentiation. In the present study, we investigated the effects of TGF-beta 1 and -beta 2 on the survival, neurite sprouting and process elongation of primary cultured hippocampal neurons obtained from rat embryos. Addition of TGF-beta 1 little affected the total number of surviving neurons, but clearly increased the number of neurons bearing processes, indicating that TGF-beta 1 promotes neurite sprouting rather than neuronal survival. Furthermore, TGF-beta 1 significantly promoted the elongation of axon-like processes, but did not affect the process branching and the number of dendrite-like processes. TGF-beta 2 also promoted the neurite sprouting and stimulated the elongation of axons without affecting the branching. The effects of TGF-beta 2 were very similar to those of TGF-beta 1 in terms of both effective concentrations (0.1-1 ng/ml) and maximal effects. It is possible that TGF-beta 1 and -beta 2 play roles in the formation of neuritic networks in the central nervous system.

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Research works printed but not linked: 23

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Metadata

Authors
Ishihara, A., Saito, H., & Abe, K.
Affiliations
The University of Tokyo (JP)
Corresponding author
Abe, Kazuho
Venue
Brain Research
Publisher
Elsevier BV
Published
1994-03
Volume
639
Issue
1
Pages
21-25
ISSN
0006-8993 (ISSN-L)
DOI
10.1016/0006-8993(94)91759-0
OpenAlex
W2090765081
Cited by
75
References
1
Citations by year
2026: 2 · 2023: 1 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 1 · 2015: 2 · 2014: 2 · 2013: 4 · 2012: 3
FWCI
1.72
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords
TGF-β1, transforming growth factor-beta2, neurite sprouting, neurite elongation, hippocampal neurons, axon development, neuronal survival, dendritic branching, growth factor signaling
MeSH terms
Animals, Axons, Cell Survival, Cells, Cultured, Hippocampus, Neurons, Transforming Growth Factor beta, Neurites, Rats, Wistar, Rats

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