Castration reduces vasopressin receptor binding in the hamster hypothalamus
Abstract
A recently developed ligand with very high affinity and selectivity for the vasopressin (AVP) V1a receptor subtype (i.e. [125I]Linear AVP antagonist ([125I]-LinAntag) was used to describe the distribution of AVP binding sites in the hamster brain, and to determine whether AVP receptor binding was influenced by testicular hormones in sites involved in the regulation of steroid-dependent social behaviors. These studies demonstrated [125I]LinAntag binding in regions of the hamster brain which have not been previously identified with other AVP ligands. In addition, testicular hormones were found to alter [125I]LinAntag binding in two distinct regions, the posterior lateral preoptic-anterior lateral hypothalamic continuum and the posterior ventrolateral hypothalamic nucleus and adjacent tuberal area.
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In hamsters, the lateral septum contains large numbers of V1aRs, but few, if any, AVP-containing fibers or cell bodies have been identified with immunohistochemistry.
“For example, in hamsters the lateral septum contains large numbers of V1aRs but few, if any, AVP containing fibers or cell bodies have been identified with immunohistochemistry [112; 113; 114; 115].”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [112]
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References 23 · Cited by 65
- Authors
- Johnson, A. E., Barberis, C., & Elliott Albers, H.
- Affiliations
- Uppsala University (SE)
- Inserm (FR)
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1995-03
- Volume
- 674
- Issue
- 1
- Pages
- 153-158
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2050854736
- Cited by
- 65
- References
- 23
- Citations by year
- 2024: 2 · 2022: 2 · 2020: 2 · 2019: 2 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 5 · 2012: 2
- FWCI
- 7.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- vasopressin V1a receptor, castration, testicular hormones, hypothalamus, receptor binding sites, hamster, social behavior
- MeSH terms
- Animals, Arginine Vasopressin, Autoradiography, Binding Sites, Cricetinae, Hypothalamus, Male, Orchiectomy, Tissue Distribution, Receptors, Vasopressin
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