Increased density of μ-opioid receptors in the postmortem brain of suicide victims
Abstract
The biochemical status of mu-opioid receptors in suicide was evaluated by [3H]DAGO specific binding in postmortem human brains from 15 suicide victims and 15 controls. The density (Bmax) in frontal cortex and thalamus was directly correlated with age. In the frontal cortex and caudate but not in the thalamus of suicide victims the density of mu-opioid receptors was 36-39% higher than in controls. KD values in suicide victims were similar to those in control group (range 1.4-2.2 nM). The results suggest an increase of mu-opioid receptors in suicide associated to some brain areas showing the mu2-opioid receptor subtype.
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Post-mortem studies on depressed patients who committed suicide revealed increased mu-opioid receptor expression, which may refer to endogenous endorphin insufficiency and can explain, at least partially, the efficacy of buprenorphine on depression.
“Furthermore, post-mortem studies (conducted on depressed patients who committed suicide) revealed an increased µ-opioid receptor expression which may refer to an endogenous endorphin insufficiency [54], and can explain, at least partially, the efficacy of BUP on depression.”
From The Efficacy of Buprenorphine in Major Depression, Treatment-Resistant Depression and Suicidal Behavior: A Systematic Review (2018) · cites this paper as [54]
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References 38 · Cited by 131
- Authors
- Gabilondo, A. M., Javier Meana, J., & García-Sevilla, J. A.
- Affiliations
- University of the Basque Country (ES)
- ORCID
- Gabilondo, Ane M.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1995-06
- Volume
- 682
- Issue
- 1-2
- Pages
- 245-250
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2054123223
- Cited by
- 131
- References
- 38
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 7 · 2021: 5 · 2020: 8 · 2019: 7 · 2018: 8 · 2017: 8 · 2016: 6 · 2015: 3 · 2014: 8 · 2013: 1 · 2012: 4
- FWCI
- 0.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- mu-opioid receptor, suicide, postmortem brain, receptor density, frontal cortex, thalamus, caudate nucleus, age-related changes
- MeSH terms
- Adult, Aged, Aged, 80 and over, Amino Acid Sequence, Analgesics, Brain Chemistry, Enkephalins, Female, Humans, Kinetics, Male, Middle Aged, Molecular Sequence Data, Postmortem Changes, Suicide, Receptors, Opioid, mu, Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
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