Endogenous glucocorticoids down regulate central effects of interleukin-1 β on body temperature and behaviour in mice
Abstract
Adrenalectomy sensitizes laboratory animals to the pyrogenic and behavioural effects of proinflammatory cytokines. To determine whether these effects are mediated by central sites of action of glucocorticoids, interleukin-1 beta was injected intracerebroventricularly (i.c.v.) in adrenalectomized mice with or without corticosterone supplementation and in mice pretreated i.c.v. with the glucocorticoid type II receptor antagonist RU38486. Adrenalectomized mice were more sensitive to the depressing effects of i.c.v. IL-1 beta on body temperature and social exploration than sham-operated mice. Corticosterone supplementation reversed the increased sensitivity to the low (300 pg/mouse) but not to the high dose (900 pg/mouse) of IL-1 beta. Central administration of RU38486 (0.5-1 microgram/mouse) mimicked the effects of adrenalectomy on behaviour but not on body temperature. These results suggest that endogenous glucocorticoids released in response to IL-1 beta act in the brain to modulate the sensitivity of the cellular targets of this cytokine.
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Exacerbated levels of pro-inflammatory cytokines were found in the brain of adrenalectomized mice following a subcutaneous injection of LPS.
“Almost 20 years ago, exacerbated levels of pro-inflammatory cytokines were found in the brain of adrenalectomized mice following a sub-cutaneous injection of LPS (127–130).”
From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [128]
Substantial evidence established that GCs restrain and/or terminate the innate immune response in the CNS following either a peripheral or cerebral challenge.
“Substantial evidence established that GCs restrain and/or terminate the innate immune response in the CNS following either a peripheral or cerebral challenge.”
From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [128]
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References 40 · Cited by 45
- Authors
- Goujon, E., Parnet, P., Cremona, S., & Dantzer, R.
- Affiliations
- Inserm (FR)
- Corresponding author
- Dantzer, Robert
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1995-12
- Volume
- 702
- Issue
- 1-2
- Pages
- 173-180
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2055224414
- Cited by
- 45
- References
- 40
- Citations by year
- 2018: 1 · 2016: 1 · 2015: 2 · 2014: 3
- FWCI
- 2.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- glucocorticoids, IL-1β, adrenalectomy, corticosterone, mifepristone, body temperature, social exploration, inflammatory cytokines, pyrogenic effect, central sensitization
- MeSH terms
- Animals, Behavior, Animal, Body Temperature, Dose-Response Relationship, Drug, Glucocorticoids, Interleukin-1, Male, Mice, Inbred Strains, Time Factors, Down-Regulation, Mifepristone, Mice
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