Apolipoprotein E (apoE) levels in brains from Alzheimer disease patients and controls
Abstract
We measured apolipoprotein E (apoE) level in neutral and acidic pH extracts of the frontal, temporal and cerebellar cortices from patients with definite Alzheimer's disease (AD) and controls, and analyzed the relationship among apoE levels, clinical and neuropathological findings, and apoE genotype. Our data showed that the levels varied in different brain regions being lowest in the frontal cortex and highest in the cerebellum in Ad brains. ApoE levels in neutral pH extracts from the frontal cortex from AD patients were significantly lower than those of controls, and correlated negatively with the number of neurofibrillary tangles. ApoE genotype was not associated with the levels of apoE. There was no correlation between apoE levels and amyloid load or synaptophysin-immunoreactivity in the brain. We conclude that apoE levels are not increased in AD brains. However, apoE levels vary in different brain regions, and local factors related to the synthesis and metabolism of apoE may be crucial in the pathogenesis of AD.
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ApoE levels may be artificially altered by postmortem delay.
“In addition, apoE levels may be artificially altered by postmortem delay (Pirttila et al., 1996).”
From The role of apolipoprotein E in Alzheimer's disease (2009) · cites this paper as Pirttila et al., 1996
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Ma, J., Yee, A., Brewer, H. B., Das, S., & Potter, H. (1994) · Nature · doi:10.1038/372092a0 · Cited by 871 · see citing works
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The role of apolipoprotein E in Alzheimer's disease
Kim, J., Basak, J. M., & Holtzman, D. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.06.026 · Cited by 1,661 · see citing works
Uddin, M. S., Kabir, M. T., Al Mamun, A., Abdel-Daim, M. M., Barreto, G. E., & Ashraf, G. M. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1237-z · Cited by 212 · see citing works
Bien-Ly, N., Gillespie, A. K., Walker, D., Yoon, S. Y., & Huang, Y. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0033-12.2012 · Cited by 170 · see citing works
Nilselid, A.-M., Davidsson, P., Nägga, K., Andreasen, N., Fredman, P., & Blennow, K. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2005.12.005 · Cited by 104 · see citing works
ApoE4 reduction: An emerging and promising therapeutic strategy for Alzheimer's disease
Li, Y., Macyczko, J. R., Liu, C.-C., & Bu, G. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2022.03.011 · Cited by 61 · see citing works
ApoE expression across the CNS: Who, What, Where, When, and How (much)?
Nolt, G. L., Lucido, C. C., Smith, L. M., & Johnson, L. A. (2026) · Molecular Neurodegeneration Advances · doi:10.1186/s44477-026-00028-x · Cited by 2 · see citing works
- Authors
- Pirttilä, T., Soininen, H., Heinonen, O., Lehtimäki, T., Bogdanovic, N., Paljärvi, L., Kosunen, O., Winblad, B., Riekkinen, P., Wisniewski, H. M., & Mehta, P. D.
- Affiliations
- Tampere University Hospital (FI)
- Kuopio University Hospital (FI)
- Karolinska Institutet (SE)
- Corresponding author
- Mehta, P.D.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1996-05
- Volume
- 722
- Issue
- 1-2
- Pages
- 71-77
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2002589314
- Cited by
- 42
- References
- 1
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 1 · 2021: 2 · 2019: 3 · 2018: 2 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG04220, P01AG004220)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- apolipoprotein E, Alzheimer's disease, frontal cortex, cerebellum, neurofibrillary tangles, amyloid load, synaptophysin, APOE genotype
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Apolipoproteins E, Brain, Enzyme-Linked Immunosorbent Assay, Genotype, Humans, Immunohistochemistry, Phenotype, Reference Values, Time Factors, Synaptophysin, Neurofibrillary Tangles
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