Transforming growth factor-β1 promotes re-elongation of injured axons of cultured rat hippocampal neurons
Abstract
Transforming growth factor-beta 1 (TGF-beta 1) is highly expressed in neural tissues following brain injuries. To determine a role of TGF-beta 1 in neural pathologies, axons of cultured rat hippocampal neurons were cut by local irradiation of laser beam, and the effect of TGF-beta 1 on neurite regeneration following axotomy was investigated. The axonal growth was stopped by laser irradiation, but addition of TGF-beta 1 remarkably promoted the axonal re-elongation from the injured site. The effect of TGF-beta 1 was concentration dependent and seen maximally at a concentration of 1 ng/ml. These results suggest that TGF-beta 1 has a capability of promoting axonal regeneration of brain neurons after lesioning.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In humans, the initial cloning studies of GAP43 showed that it is induced in peri-infarct cortex after stroke and increases cortical thickness in regions of cortical map plasticity during recovery.
“In humans, the initial cloning studies of GAP43, the paradigmatic neuronal growth cone marker, showed that it is induced in peri-infarct cortex after stroke39 and increases cortical thickness in regions of cortical map plasticity during recovery7.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [39]
In other in vitro systems, TGFβ promotes axonal outgrowth of injured neurons and blockade of TGFβRII alters neuronal polarity and leads to shorter axons.
“In other in vitro systems, TGFβ promotes axonal outgrowth of injured neurons21,22,39,40 and blockade of TGFβRII alters neuronal polarity and leads to shorter axons42.”
From GDF10 is a signal for axonal sprouting and functional recovery after stroke (2015) · cites this paper as [39]
No citation lists for this paper
No citation lists for this paper yet — checked again daily.
References 25 · Cited by 51
- Authors
- Abe, K., Chu, P.-J., Ishihara, A., & Saito, H.
- Affiliations
- The University of Tokyo (JP)
- Corresponding author
- Abe, Kazuho
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1996-06
- Volume
- 723
- Issue
- 1-2
- Pages
- 206-209
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2070173108
- Cited by
- 51
- References
- 25
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 3 · 2017: 2 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 3
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- TGF-β1, axon regeneration, axotomy, hippocampal neurons, brain injury, neurotrophic factors
- MeSH terms
- Animals, Axons, Cells, Cultured, Dose-Response Relationship, Drug, Hippocampus, Transforming Growth Factor beta, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
