Cited by 92Insect Resistance and GeneticsPesticide Exposure and ToxicityNeurobiology and Insect Physiology Research

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Drosophila acetylcholinesterase: Mechanisms of resistance to organophosphates

Fournier, Didier, Mutero, Annick, Pralavorio, Madeleine, Bride, Jean-Marc·1993·Chemico-Biological Interactions

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Abstract

Quantitative and qualitative changes of acetylcholinesterase can affect the sensitivity of insects to insecticides. First, the amount of acetylcholinesterase in the central nervous system is important in Drosophila melanogaster, flies which overexpress the enzyme are more resistant than wild-type flies. On the contrary, flies which express low levels of acetylcholinesterase are more susceptible. An overproduction of acetylcholinesterase outside the central nervous system also protects against organophosphate poisoning, that is, flies producing a soluble acetylcholinesterase, secreted in the haemolymph, are resistant to organophosphates. Second, resistance can also result from a qualitative modification of acetylcholinesterase. Four mutations have been identified in resistant strains: Phe115 to Ser, Ileu199 to Val, Gly303 to Ala and Phe368 to Tyr. Each of these mutations led to a different pattern of resistance and combinations between these mutations led to highly resistant enzymes.

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Authors: Fournier, D., Mutero, A., Pralavorio, M., & Bride, J.-M.
Affiliations: Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR)
Corresponding author: Fournier, Didier
Venue: Chemico-Biological Interactions
Publisher: Elsevier BV
Published: 1993-06
Volume: 87
Issue: 1-3
Pages: 233-238
ISSN: 0009-2797 (ISSN-L)
DOI: 10.1016/0009-2797(93)90047-3
OpenAlex: W2061182635
Cited by: 92
References: 16
Citations by year: 2026: 1 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 1 · 2019: 3 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 5 · 2013: 2 · 2012: 5
FWCI: 0.52
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Chemico-Biological Interactions (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: London School of Hygiene and Tropical Medicine
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Insect Resistance and Genetics
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords: acetylcholinesterase, organophosphate resistance, Drosophila melanogaster, insecticide resistance, enzyme overexpression, hemolymph, central nervous system, enzyme mutations, insecticide susceptibility
MeSH terms: Acetylcholinesterase, Animals, Cholinesterase Inhibitors, Drosophila melanogaster, Insecticide Resistance, Insecticides, Organophosphorus Compounds, Point Mutation

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Drosophila acetylcholinesterase: Mechanisms of resistance to organophosphates

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