The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
A longitudinal study on cortisol, prolactin and thyroid hormones in users of norplantR subdermal implants or a copper T device
Abstract
A longitudinal study was undertaken to assess PRL, cortisol, TSH, T3 and T4 levels in NORPLANT implant users (n = 22) and Copper T users (n = 20). Participants were healthy women with no contraindication for hormonal contraception. Samples were drawn at 0930 to 1000 h twice pretreatment and at month 2, 4, 6, 12, 24 and 36 after insertion. At the second treatment month, a second sample was obtained at 1600 h to assess cortisol diurnal variation. Hormones were measured by RIA. Values for all hormones were similar in Norplant and Copper T users. No significant changes occurred throughout the study period. Elevated PRL levels (greater than 500 mU/1) were found in three women from each group before and during treatment but no clinical evidence of hyperprolactinemia was detected. The results of this study reassure that long-term use of NORPLANT implants do not impair plasma levels of cortisol, prolactin and thyroid hormones.
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“This COC-induced increase of CBG plateaus after just over a week of COC use and weans off 4 to 6 weeks after discontinuation (11, 13-17).”
From Salivary Cortisol and Cortisone Can Circumvent Confounding Effects of Oral Contraceptives in the Short Synacthen Test (2024) · cites this paper as [16]
Citations
Cites
Methods of Hormone Radioimmunoassay
(1978) · Elsevier eBooks · doi:10.1016/b978-0-123-79260-0.x5001-8 · Cited by 2,082
A Radioimmunoassay for Measurement of Thyroxine in Unextracted Serum*
CHOPRA, I. J. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-34-6-938 · Cited by 539
International Experience with NORPLANT and NORPLANT-2 Contraceptives
Sivin, I. (1988) · Studies in Family Planning · doi:10.2307/1966493 · Cited by 236
Radioimmunassay for measurement of triiodothyronine in human serum
Chopra, I. J., Solomon, D. H., & Beall, G. N. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106696 · Cited by 119
Croxatto, H. B., Dı́az, S., Robertson, D. N., et al. (1983) · Contraception · doi:10.1016/0010-7824(83)90006-9 · Cited by 61
Self-citationLong-term reversible contraception with levonorgestrel-releasing Silastic rods
Roy, S., Mishell, D. R., Robertson, D. N., et al. (1984) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(84)90544-1 · Cited by 46
Effect of subdermal levonorgestrel contraceptive implants, NORPLANT®, on serum lipids
Shaaban, M. M., Elwan, S. I., Abdalla, S. A., & Darwish, H. A. (1984) · Contraception · doi:10.1016/0010-7824(84)90033-7 · Cited by 43
A three-year clinical trial with levonorgestrel silastic implants
Dı́az, S. (1979) · Contraception · doi:10.1016/0010-7824(79)90004-0 · Cited by 38
Self-citationEffect of subdermal levonorgestrel contraceptive implants, NORPLANT®, on liver functions
Shaaban, M. M., Elwan, S. I., El-Sharkawy, M. M., et al. (1984) · Contraception · doi:10.1016/0010-7824(84)90032-5 · Cited by 36
Hormonal changes during the first year of use of subdermal levonoregestrel implants, NORPLANT®
Shaaban, M. M., Elnashar, I., Ghaneimah, S. A., et al. (1984) · Contraception · doi:10.1016/0010-7824(84)90031-3 · Cited by 28
Research works printed but not linked: 2
- World Health Organization, 1985, Facts about an implantable contraceptive, Bulletin of the World Health Organization, 63, 485
- Who Special Programme of Research, Development and Research Training in Human Reproduction, 1987, Programme for the Provision of Matched Assay Reagents for the RIA of Hormone in Reproductive Physiology, Method Manual
Cited by
Bäcklund, N., Lundstedt, S., Tornevi, A., Wihlbäck, A.-C., Olsson, T., Dahlqvist, P., & Brattsand, G. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad763 · Cited by 13
Metadata
- Authors
- Díaz, S., Pavez, M., Brandeis, A., Cárdenas, H., & Croxatto, H. B.
- Affiliations
- Instituto Chileno de Medicina Reproductiva (CL)
- ORCID
- Cárdenas, H.
- Venue
- Contraception
- Publisher
- Elsevier BV
- Published
- 1989-10
- Volume
- 40
- Issue
- 4
- Pages
- 505-517
- ISSN
- 0010-7824 (ISSN-L)
- OpenAlex
- W1965038260
- Cited by
- 11
- References
- 13
- Citations by year
- 2024: 1 · 2020: 1
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Contraception (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- Norplant, subdermal contraceptive implant, Copper T, hormonal contraception, prolactin, cortisol, thyroid-stimulating hormone, thyroid hormones, hyperprolactinemia, diurnal cortisol rhythm
- MeSH terms
- Adult, Contraceptive Agents, Female, Drug Implants, Female, Humans, Hydrocortisone, Intrauterine Devices, Copper, Longitudinal Studies, Norgestrel, Prolactin, Thyroid Hormones, Thyrotropin, Thyroxine, Triiodothyronine, Levonorgestrel
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- CoChat. (2026). Citation check: A longitudinal study on cortisol, prolactin and thyroid hormones in users of norplantR subdermal implants or a copper T device. https://app.cochat.ai/papers/10.1016/0010-7824(89)90056-5
- The paper
- Díaz, S., Pavez, M., Brandeis, A., Cárdenas, H., & Croxatto, H. B. (1989). A longitudinal study on cortisol, prolactin and thyroid hormones in users of norplantR subdermal implants or a copper T device. Contraception. https://doi.org/10.1016/0010-7824(89)90056-5
