The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Chemotactic response of nerve fiber elongation to nerve growth factor
Abstract
Abstract These studies seek to determine whether the locomotory behavior of the extending tip of growing nerve fibers exhibits chemotaxis to nerve growth factor (NGF). Sensory neurons from dissociated dorsal root ganglia of chick embryos were cultured within semisolid agar matrices containing concentration gradients of NGF which diffused from an adjacent source. A preferential orientation of approximately 60% of the tips of nerve fibers and an enhanced extension of fibers up NGF gradients were observed. The initiation sites of nerve fibers on cell bodies were not consistently oriented by these NGF gradients. Orientation of nerve fiber extension toward the NGF source was observed in chambers with NGF sources ranging from 25 to 1000 ng/ml of β-NGF and from 400 to 5000 ng/ml of 7 S NGF, but no orientation was observed when the concentration of the NGF source was 15000 ng/ml of β-NGF. This oriented response apparently is not a concentration-dependent trophic response to NGF. The evidence supports the notion that chemotaxis is a regulatory factor in neuronal morphogenesis.
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Citations
Cites
N-formylmethionyl peptides as chemoattractants for leucocytes.
Schiffmann, E., Corcoran, B. A., & Wahl, S. M. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.3.1059 · Cited by 881
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Local control of neurite development by nerve growth factor
Campenot, R. B. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.10.4516 · Cited by 746
Cell-to-substratum adhesion and guidance of axonal elongation
Letourneau, P. C. (1975) · Developmental Biology · doi:10.1016/0012-1606(75)90379-6 · Cited by 677
Self-citationThe retrograde axonal transport of nerve growth factor
Hendry, I. A., Sto¨ckel, K., Thoenen, H., & Iversen, L. L. (1974) · Brain Research · doi:10.1016/0006-8993(74)90536-8 · Cited by 597
Principles of Cell Motility: The Direction of Cell Movement and Cancer Invasion
CARTER, S. B. (1965) · Nature · doi:10.1038/2081183a0 · Cited by 494
Possible roles for cell-to-substratum adhesion in neuronal morphogenesis
Letourneau, P. C. (1975) · Developmental Biology · doi:10.1016/0012-1606(75)90378-4 · Cited by 444
Self-citationTHE REGULATORY ROLE OF DIVALENT CATIONS IN HUMAN GRANULOCYTE CHEMOTAXIS
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Cited by
Edelman, G. M. (1983) · Science · doi:10.1126/science.6823544 · Cited by 1,015
Expression and structure of the human NGF receptor
Johnson, D., Lanahan, A., Buck, C. R., Sehgal, A., Morgan, C., Mercer, E., Bothwell, M., & Chao, M. (1986) · Cell · doi:10.1016/0092-8674(86)90619-7 · Cited by 963
Chemotropic guidance of developing axons in the mammalian central nervous system
Tessier-Lavigne, M., Placzek, M., Lumsden, A. G. S., Dodd, J., & Jessell, T. M. (1988) · Nature · doi:10.1038/336775a0 · Cited by 694
Turning of nerve growth cones induced by neurotransmitters
Zheng, J. Q., Felder, M., Connor, J. A., & Poo, M.-M. (1994) · Nature · doi:10.1038/368140a0 · Cited by 580
Davies, A. M., Bandtlow, C., Heumann, R., Korsching, S., Rohrer, H., & Thoenen, H. (1987) · Nature · doi:10.1038/326353a0 · Cited by 548
Metadata
- Authors
- Letourneau, P. C.
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 1978-09
- Volume
- 66
- Issue
- 1
- Pages
- 183-196
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W2072463822
- Cited by
- 277
- References
- 33
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- closed
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
