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Asbestos-activated peritoneal macrophages release a factor(s) which inhibits lymphocyte mitogenesis

Donaldson, Kenneth, Davis, J.M.G., James, Keith·1984·Environmental Research
DOI 10.1016/0013-9351(84)90117-8
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Abstract

Intraperitoneal asbestos injection in mice has previously been reported to elicit an activated macrophage population. In the present study supernatants from such macrophages were tested for their effect on thymocyte mitogenesis in response to concanavalin A; control supernatants were obtained from saline- and latex-elicited macrophages. Supernatants from asbestos-elicited macrophages were significantly inhibitory to thymocyte mitogenesis while saline- and latex-elicited macrophages did not release significant amounts of such activity. Asbestos-activated macrophage supernatants were inhibitory in a dose-dependent way and the activity was not secreted by macrophages from mice which had received asbestos in the long term. The inhibitory activity was partially dialysable. Supernatants prepared by treating macrophages in vitro with a lethal dose of asbestos were not inhibitory suggesting that the inhibitory activity in the supernatants of asbestos-activated macrophages did not leak from dead or dying cells. The asbestos macrophage supernatant was also significantly inhibitory to mature T-cell-enriched spleen cells but had no effect on fibroblasts, suggesting that the inhibitory effect could be lymphoid cell specific.

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Research works printed but not linked: 37

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Metadata

Authors
Donaldson, K., Davis, J. M. G., & James, K.
Venue
Environmental Research
Publisher
Elsevier BV
Published
1984-10
Volume
35
Issue
1
Pages
104-114
ISSN
0013-9351
DOI
10.1016/0013-9351(84)90117-8
Cited by
6
References
0
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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CoChat. (2026). Citation check: Asbestos-activated peritoneal macrophages release a factor(s) which inhibits lymphocyte mitogenesis. https://app.cochat.ai/papers/10.1016/0013-9351(84)90117-8
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Donaldson, K., Davis, J. M. G., & James, K. (1984). Asbestos-activated peritoneal macrophages release a factor(s) which inhibits lymphocyte mitogenesis. Environmental Research. https://doi.org/10.1016/0013-9351(84)90117-8